Localized Surface Plasmon Resonance (LSPR) sensors have potential applications in essential and important areas such as bio-sensor technology, especially in medical applications and gas sensors in environmental monitoring applications. Figure of Merit (FOM) and Sensitivity (S) measurements are two ways to assess the performance of an LSPR sensor. However, LSPR sensors suffer low FOM compared to the conventional Surface Plasmon Resonance (SPR) sensor due to high losses resulting from radiative damping of LSPs waves. Different methodologies have been utilized to enhance the performance of LSPR sensors, including various geometrical and material parameters, plasmonic wave coupling from different structures, and integration of noble metals with graphene, which is the focus of this report. Recent studies of metal-graphene hybrid plasmonic systems have shown its capability of promoting the performance of the LSPR sensor to a level that enhances its chance for commercialization. In this review, fundamental physics, the operation principle, and performance assessment of the LSPR sensor are presented followed by a discussion of plasmonic materials and a summary of methods used to optimize the sensor’s performance. A focused review on metal-graphene hybrid nanostructure and a discussion of its role in promoting the performance of the LSPR sensor follow.

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Integrating plasmonic materials, like gold with a two-dimensional material (e.g., graphene) enhances the light-material interaction and, hence, plasmonic properties of the metallic nanostructure. A localized surface plasmon resonance sensor is an effective platform for biomarker detection. They offer a better bulk surface (local) sensitivity than a regular surface plasmon resonance (SPR) sensor; however, they suffer from a lower figure of merit compared to that one in a propagating surface plasmon resonance sensors. In this work, a decorated multilayer graphene film with an Au nanostructures was proposed as a liquid sensor. The results showed a significant improvement in the figure of merit compared with other reported localized surface plasmon resonance sensors. The maximum figure of merit and intensity sensitivity of 240 and 55 RIU−1 (refractive index unit) at refractive index change of 0.001 were achieved which indicate the capability of the proposed sensor to detect a small change in concentration of liquids in the ng/mL level which is essential in early-stage cancer disease detection.

Although localized surface plasmonic resonance (LSPR) sensors have advantages over regular surface plasmonic resonance (SPR) sensors, such as in sensor setup, excitation method, and cost, they suffer from low performance when compared to SPR sensors, which thus limits their commercialization. Among different methods applied to promote LSPR sensor performance, metal-two-dimensional (2D) hybrid nanostructure has been shown to be an efficient improvement. However, metal-2D hybrid nanostructures may come in a complex or a simple scheme and the latter is preferred to avoid challenges in fabrication work and to be applicable in mass production. In this work, a new and simple gold-graphene hybrid scheme is proposed and its plasmonic sensing performance is numerically evaluated using the finite different time domain (FDTD) method. The proposed sensor can be fabricated by growing a Au nano-disk (ND) array on a quartz substrate and then spin-coating graphene flakes of different sizes and shapes randomly on top of and between the Au NDs. Very high sensitivity value is achieved with 2262 nm/RIU at a 0.01 refractive index change. The obtained sensitivity value is very competitive in the field of LSPR sensors using metal-2D hybrid nanostructure. This proposed sensor can be utilized in different biosensing applications such as immunosensors, sensing DNA hybridization, and early disease detection, as discussed at the end of this article.