Schwann cells were identified in the tumor surrounding area prior to initiate the invasion process underlying connective tissue. These cells promote cancer invasion through direct contact, while paracrine signaling and matrix remodeling are not sufficient to proceed. Considering the intertwined structure of signaling, regulatory, and metabolic processes within a cell, we employed a genome-scale biomolecular network. Accordingly, a meta-analysis of Schwann cells associated transcriptomic datasets was performed, and the core information on differentially expressed genes (DEGs) was obtained by statistical analyses. Gene set over-representation analyses was performed on core DEGs to identify significantly functional and pathway enrichment analysis between Schwann cells and, lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). DEGs were further integrated with genomescale human biomolecular networks. miRNAs were proposed by the reconstruction of a transcriptional and post-transcriptional regulatory network. Moreover, microarraybased transcriptome profiling was performed, and the prognostic power of selected dedifferentiated Schwann cell biomolecules was predicted. We observed that pathways associated with Schwann cells dedifferentiation was overexpressed in lung cancer samples. However, genes associated with Schwann cells migration inhibition system were downregulated. Besides, miRNA targeting those pathways were also deregulated. In this study, we report valuable data for further experimental and clinical analysis, because the proposed biomolecules have significant potential as systems biomarkers for screening or for therapeutic purposes in perineural invasion of lung cancer.

Stress was interpreted as a nonspecific reaction of the organism to a situation that would threaten its homeostasis. Several factors in the modern world can be related to this condition: the search for a perfect body, the labor market dispute or the pressure to conquer everything as fast as possible. Associated with these factors, one can add the intense, naturally stressful, routine in which man is inserted. At the experimental level, several effects are observed at a systemic and behavioral level in rats that have been submitted to food restriction models, finding that the gastrointestinal system is quite vulnerable to stress in general. In specific cases of food stress, it was observed that the manifestations vary according to the life stage of the animal and the applied model. In this sense, the present research aims to evaluate the influence of food restriction on the intestinal tunica morphology of rats submitted to a chronic food stress model. For this, 27 animals were divided into control (n = 11) and test (n = 16) groups. From the 60 th day of life, the test group was submitted to four stages, each one being performed in one day: 1) palatable diet; 2) visual stimulation to the diet, but without access; 3) fasting; 4) standard diet of the biotery. The four steps were repeated until the animals completed 90 days. In the morphometry of the duodenum were analyzed: length, width and area of vill, as well as area of intestinal gland (Lieberkühn). Statistical inference of data showed that the applied stress model affected the morphology of the stressed group, since the intestinal villi appeared wider and with less area in this group. The villi length as well as the intestinal gland area did not undergo morphological changes. The alterations found reinforce that the fasting process acts as a stressor and a predisposing factor for morphological alterations, as observed in other studies in our laboratory. However, there are not many studies in the literature that allow the knowledge of the consequences of this type of stress. In this case, further research is needed on the relationship between the gastrointestinal tract and the experimental model applied to elucidate such findings.

Protein malnutrition during the perinatal period leads to several morphological and physiological changes in the central nervous system whose main purpose is to prepare the body for environmental conditions. Several studies have been developed to explain the effects that malnutrition causes over feeding behavior in adults, and in particular on the role of the serotonergic system in this control. Thus, the objective of this systematic review was to assess emerging literature on the effects of perinatal malnutrition on the control of feeding behavior and the role of the serotonergic system in this control. The articles were researched in the virtual libraries Pubmed, Lilacs and Medline using as keywords:

Effects of chronic food stress on morphometry and expression of nuclear organizing regions in the adult rats hippocampus Chronic food stress on morphometry and expression of agnor in the rats hippocampusEfeitos do estresse alimentar crônico na morfometria e expressão das regiões de organização nuclear nos ratos adultos hipocampo Testemunho crônico de alimentação sobre morfometria e expressão do agnor no hippocampus das taxas

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