HIPEC is a complement to radical surgery/ peritonectomy, which has been shown to be a surgical procedure with high tolerability, low morbimortality, enhanced survival and prolonged disease-free interval in patients with peritoneal carcinomatosis for recurrent ovarian cancer.

No abstract

International audienc

Summary:We have previously demonstrated that a large V wave in the pulmonary capillary wedge tracing may occur in the absence of mitral regurgitation. This study evaluates the role of left atrial and pulmonary vein compliance on such a finding. We studied 11 patients with coronary disease, without clinical or angiographic mitral regurgitation. Heart rate, pulmonary capillary wedge mean, A and V waves, V-wave slope, left ventricular and aortic pressures, cardiac output, and left atrial echo and apical phonocardiogram were recorded simultaneously. Preload was modified acutely by volume overload and by the administration of i.v. nitroglycerine. Volume administration induced a marked increase in V-wave pressure (13.0f9.6 vs. 27.0f9.6 mmHg, p<0.05), without producing mitral regurgitation, and without appreciable change in left atrial dimension by echo (33.0f4.9 vs. 3 5 3 5 . 2 mm, NS), or stroke volume (101.7f26.2 vs. 97.8f34.3 ml, NS). An increase was also seen in the A wave ( I 3.6f8.9 vs. 23.3f8.5 mmHg, p<0.05), pulmonary capillary wedge mean pressure (9.8f7.2 vs. 20.6f7.8 mmHg, p<0.05), and left ven- tricular diastolic pressure (7.4f5.5 vs. 14.6f6.3 mmHg, p<0.05). All values returned to baseline after nitroglycerine. The compliance of the left atrium/pulmonary veins decreased with increasing pulmonary capillary wedge pressures. With large filling volumes, a small stroke volume brings on a large pressure change, thus explaining the finding of large V waves in patients with elevated pulmonary capillary wedge pressure and without mitral regurgitation.

No abstract