No abstract

are synthesized and their HIV-1 antiprotease activity is determined. -(KIRKIACHARIAN*, S.; DUONG THANH THUY; SICSIC, S.; BAKHCHINIAN, R.; KURKJIAN, R.; TONNAIRE, T.; Farmaco 57 (2002) 9, 703-708; Lab. Chim. Therap., Fac. Pharm., BIOCIS, F-92296 Chatenay-Malabry, Fr.; Eng.) -R. Langenstrassen 04-129

New routes are described for the synthesis of diethyl arylsulfonylmalonic esters and various conveniently substituted derivatives of 3-arylsulfonyl-4-hydroxycoumarin and 3-arylsulfonyl-4-hydroxy-1H-quinolin-2-one. The latter were prepared by thermal condensation of diethyl arylsulfonylmalonic esters with substituted phenols and N-substituted aniline. Study of their anti-HIV-1, anti-HIV-2, and various other antiviral properties did not reveal interesting activity.