Science literacy is the main key to face challenges in the 21st century. The research aimed to describe the students abilities of science literacy on chemical equilibrium topic through implementation of guided inquiry learning model. The research design used is One-Group Pretest-Posttest Design. The research was conducted in class XI MIPA 4 of SMAN 3 Surabaya. Data obtained by instruments of multiple-choice tests of scientific literacy and observation sheet. The results showed that every aspect of students’ scientific literacy ability was increased in the medium criteria, it was indicated by an average gain score of 0.6 for competence to explain scientific phenomena and to evaluate data and design scientific investigations. Moreover competence of interpreting data and scientific evidence obtains gain score of 0.7. The result of this research indicated that the ability of scientific literacy had been trained to students.