Objective: To determine the clinico-pathological and histological features of Chondroblastoma (CB). Place of study : Department of Pathology associated with Orthopaedics Department, Darbhanga Medical College and Hospital, Laheriasarai, Bihar. Methodology: The histological slides of all reported cases of CB were retrieved and reviewed for morphological features. Clinical features were noted from surgical pathology reports. Frequency of features was noted. Results: Sixty one cases of CB were identified. Pain was the most common presenting symptom. The age ranged from 10 to 38 years (mean 20 ± 1.98 years; M: F 2.5:1) with 61% patients in the second decade of life. Forty six cases occurred in long tubular bones; distal femur being most common site. Metaphysis, clavicle, temporal bone and metacarpal were also involved. Histologically, all CBs were composed of round to polygonal cells and scattered osteoclast-type multinucleated giant cells and majority had hemosiderin pigment. Chicken-wire calcifications and coarse calcifications were seen in 85% and 26% of cases respectively. A spindle cell component was seen in 54% of cases. ABC-like areas were seen in 10 cases. Mitosis ranged from 1 to 6/10 HPFs. Recurrence was seen in 2 cases. Recurrent tumor showed similar morphology when compared with the initial tumor. Conclusion: CB is a benign tumor but has potential for recurrence. Males are more affected, second decade is more common and distal femur is most common site. Metaphysis, clavicle, temporal bone and metacarpal were the rare sites of CB. Histological features predictive of recurrence were not separately identified.

Background: FNAC is considered an important procedure in the diagnosis of bone tumors because of its high accuracy. In our study FNA was performed in patients to study the role of FNAC in the diagnosis of bone tumors and to evaluate its usefulness as a diagnostic modality. Methods: Fine needle aspiration was performed on 54 patients whose age ranged between 5 – 75 years with a male to female ratio 1.84 :1 presented with various bone lesions. The bone lesions included 42 (78%) primary lesions, 5 (9.3%) metastatic deposits and 7 (12. 7%) malignancy of related structures involving the bone. Results: 47 biopsy specimens were available for cytohistological correlation and cytological ndings of 45 cases correlated with histopathology. The overall diagnostic accuracy was 95.92%, with 100% sensitivity and specicity. The predictive values of positive as well as negative test were 100%. Conclusions:Thus FNAwas found to be a safe and an extremely useful, rapid method in the preliminary diagnosis of bone lesions.

Background: A spectrum of pathological bone lesions can be presented in any form from inflammatory to neoplastic conditions. Diagnosis of all bone lesions is made by radiological modalities like plain X-ray, CT scan, MRI and bone scintigraphy. Aim and Objectives: To study histopathological features of bone lesions and correlate them with age, site and type of lesions. Material and Methods: The study was carried out at Department of Pathology associated with Orthopaedics, Darbhanga Medical College, Lahertiasarai, Bihar from April 2020 to November 2020. A total of 102 bone lesions were analyzed. Bone biopsy was performed after detailed clinical and radiological examination. After fixation, decalcification, processing and H&E staining, histopathological diagnosis was made. Results: Out of all 102 cases, 44.11% bone lesions were found between 25-50 years with male predominance. The incidence of non neoplastic lesions was 74.5% and neoplastic lesions were 25.4%. Amongst neoplastic lesions, incidence of benign tumors was 17.64% and malignant tumors were 7.8%. The Tuberculous Osteomyelitis was most common non neoplstic lesion while giant cell tumor and osteochondroma were common among benign tumors and osteosarcoma and Secondary metastasis were common among malignant bone tumors. Conclusion: Though Bone tumors are less common, if viewed in perspective of clinico radiology and histopathology, correct diagnosis can be made.

Introduction: The diagnosis of primary giant cell-rich lesion of bone is often difficult even for experienced pathologist. The diagnostic histological features are: multinucleated osteoclast-like giant cell and a mononuclear stroma. But sometimes, from the histological picture alone, it is difficult to differentiate between different lesions such as a Giant -cell tumour of bone, Aneurysmal Bone Cyst and Giant-cell Reparative Granuloma. Many of these lesions show some characteristic features such as typical anatomic location and age of the patient, which are also important supporting factor for diagnosis. Hence histopathological study with clinico-radiological correlation is mandatory for precise and accurate diagnosis. These parameters are important for the treatment and prognosis of these lesions. Aims & objective: Aims of the study were, to study Histopathology of Primary Giant cell-rich lesion of bone, to study the clinico-radiological correlation in these lesions & to study the diagnostic utility of findings these lesions. Material & method: In the present study, we have retrospectively examined 50 cases of primary giant-cell rich lesions of bone using biopsy tissue and large resected tissue material. All patients were diagnosed and treated at our institute from October 2019 to September 2020. Patients’ details, Clinical Examination, Histopathological Examination, Radiological details were studied and correlated. Result & conclusion: Common lesions under this category were Giant Cell Tumour of Bone (41), Aneurysmal Bone Cyst (04), Giant Cell-Rich Osteosarcoma, Giant Cell Reparative Granuloma (02), and Fibrous Dysplasia (01). Detailed Histopathological study and clinic-radiological correlation is very helpful to arrive at precise and accurate diagnosis. This in turn, is very helpful for precise treatment of these patients and to know the prognosis of these patients.

Objective: Many different neoplastic and non-neoplastic lesions involve the skeletal system. Clinical and radiological tools primarily assess the nature of these lesions. The aim of this study was to analyze the cystic bone lesions in a pathologic point of view. Methods:All bone cysts evaluated under the guidance of clinical information and radiological images. Descriptive data such as age, gender, tumor site, symptoms, and clinical and radiological ndings obtained from the hospital's database system. Results: There were 96 cystic bone lesions; 47 were aneurysmal bone cysts (ABCs), 37 were simple bone cysts (SBCs), one was a lesion with features of both ABC and SBC, four were intraosseous ganglia, four were epidermoid cysts, and three were hydatid cysts. The mean ages of the patients with ABCs and SBCs were 18.7 ± 12.8 years (range, 3-75 years) and 23.8 ± 13.3 years (range, 3-62 years), respectively. Most of the lesions located in the long bones. Conclusions: Cystic lesions of the bone rarely encountered in daily pathology routine. As with all conditions affecting the skeletal system, one of the most important steps towards an accurate pathological diagnosis is to perform with clinical and radiological information while evaluating the patients.