The moderate growth retardation frequently observed among children living at high altitude is usually assumed to result from hypoxic stress. However, such children are frequently from the poorer socioeconomic strata of their societies and may suffer malnutrition, poor hygiene, inadequate medical care, and overcrowding-factors also associated with growth retardation. The objective of this study was to determine if there is a statistically observable alteration in the growth of middle-class children of European ancestry during sojourn at high altitude. Semilongitudinal heightlweight measurements were gathered retrospectively from medical records of 18 boys and 17 girls who were born at low altitude, were well-nourished and clinically normal, and who had lived at Achoma, Peru (altitude 3,200 m), continuously for 9-36 months. Measurements were divided, by sex, into four cohorts: I(3-6 months at Achoma), I1 (6-12 months), 111 (12-18 months), and IV (18-24 months); initial, presojourn, height and weight were also obtained. All heights and weights were normalized with age-specific reference values. Changes in Z scores (AZ) during sojourn were calculated for each subject by subtracting the score of the presojourn value from those of cohorts I-IV. Paired t-tests revealed, among the boys, a significant decline in Z score for weight during sojourn in