Current research is aimed to identify the level of practice of twenty-first-century skills among the faculty member during the COVID-19 Pandemic at Oman College of Health Science from the point of view of students. The research sample was selected utilizing the convenience sampling method from four batches of college students. Descriptive survey design applied. The questionnaire consists of 6 dimensions (Educational art, Communication, and Sharing, Knowledge-Economy, Digital Culture, and Learning Technology, Thinking and Problem Solving, and Learning Assessment Skills). Validity and reliability were measured. The findings of this study showed that the practice level of the twenty-first-century skill among faculty members is in a moderate level. Also, there are significant variations in the responses of the study sample towards practice of twenty-first century skills by faculty members according to their gender. However, there is no significant variation according to study year variable.