Purpose of the study: This article intends to evaluate the arts and guideline set by the Prophet Muhammad in communication, who later stood prominently as the most influential communicator by Western scholars. Methodology: For this article, content analysis has been used to discuss the data from documents, such as books, journals, and other related materials which had been reviewed and referred to the Quran and Hadith.   Main Findings: This article found that the Prophet weaved the revelation with his worldly ways to the point that his way of communication became highly relevant and impactful for mankind.  Applications of this study: This article can be useful for preachers who are trying to attract the target to receive their mission. In addition, it also suggests the art of effective communication that can be applied by researchers and those who are in the field of communication. Novelty/Originality of this study: Only a very few have examined the arts and guideline set by the Prophet Muhammad in communication for the sole purpose of making life more convenient and advantageous. Hence, its use leaves a good influence on humanity.