Systemic lupus erythematosus is a chronic autoimmune inflammatory disease that can affect any part of the body.Lupus Nephritis is one of the most common, and most important, serious manifestations of SLE particularly for male. We present a case of 15 year old male that is diagnosed with a systemic lupus erythematosus (SLE) based on 6 of the American College of Rheumatology (ACR), diagnostic criteria developed namely: malar rash, arthritis, photosensitive, kidney disorders (hematuria), immunological disorders (positive anti-dsDNA), and blood disorders (anemia, leucopenia). The result of the kidney's biopsy indicated the patient already developed Lupus Nephritis.. The patient responded very well with corticosteroid. Although male patient with SLE is not commonly seen, the manifestations are life threatening and early detection of disease will lead to better outcome of the patient. Antimalaria drugs Hydrochloroquine is useful in patients with SLE glomerulonephritis. In consequences of their numerous beneficial effects, antimalarials appear to have a protective effect on survival in SLE.

AbstrakLatar belakang: Nuclear factor kappa B (NF-κB) berperan dalam proses onkogenesis. Aktifitas NF-κB pada kultur sel trofoblas mola hidatidosa komplit (MHK) AbstractBackground: Genetic evidence has established a role of nuclear factor kappa B (NF-κB) signaling in oncogenesis. However, activity of NF-κB in complete hydatidiform mole (CHM) cell culture under 17β-estradiol (E2) treatment is not yet known. Recently, a positive cross-talk between estrogen receptor (ER) and NF-κB to promote survival and progress of cancer cells to a more aggressive phenotype was established. In the present study, we examined the influence of E2 treatment on the NF-κB expression in CHM's culture.