Background: Health care workers (HCWs) are at high risk of acquiring infections during this ongoing COVID-19 outbreak. This study was aimed at determining the prevalence of SARS-CoV-2 infection, the socio demographic and clinical profile and the possible risk factors for infection among the HCWs at Mugda Medical College Hospital (MuMCH). Method: This retrospective observational study was done among the HCWs of MuMCH from 19 April, 2020 to 15 May, 2020. The SARS-CoV-2 positive 37 HCWs were interviewed over telephone by a structured questionnaire and the obtained data were analyzed by using descriptive statistics. Result: Out of total 343 HCWs, total 37(10.79%) cases were detected COVID-19 positive. Out of them, 13(35.14%) were male and 24 (64.86%) were female. The median age was 36 years. Among the infected HCWs, 26 (70.27%) did not have any pre-existing comorbidities. Bronchial asthma (13.51%) and HTN (13.51%) were the most prevalent comorbidities. Around 43.24% (16) had no definite symptoms for COVID- 19. Among the 21(56.76%) symptomatic cases, 15(40.54%) had mild and 6(16.22%) had moderate symptoms. The most common symptoms were cough (16, 43.24%), fever (11, 29.73%), sore throat (7, 18.92%) and fatigue/malaise (7, 18.92%). All had completely recovered uneventfully although 22(59.46%) got admitted to hospital. Only 12(32.43%) were involved in aerosol generating procedure. Total 26 cases (70.27%) used appropriate PPE during their duty. Although only 4(10.81%) got adequate training on PPE use, 33(89.19%) of them had adequate knowledge on that. About 15(40.54%) were reusing PPEs. Most of them (33, 89.20%) were not taking any chemoprophylaxis; all were following traditional preventive measures. Among the HCWs, 26(70.27%) were not satisfied with the infection prevention and control (IPC) measures taken by the hospital authority. All of them presumed that, their occupational exposure was the possible source of COVID-19 infection. Conclusion: More than 1 in 10 HCWs at MuMCH was infected with SARS-CoV-2 while working at the hospital. They represented the younger age group, had fewer comorbidities. Nurses were the most affected category. All experienced uneventful recovery and most of them were not satisfied with the IPC measures taken by the hospital authority. Further studies are required to identify the level of risk of infection, possible risk factors and outcomes and to improve the IPC measures of the hospital. J Bangladesh Coll Phys Surg 2020; 38(0): 43-49

Background: The novel corona virus has been identified as the cause of respiratory illness in Wuhan, Hubei province, China, since December, 2019. It has spread almost all the countries and areas (212) in world. Due to distinct demographics of infection, variation of case fatality and clinical presentation in different countries, the knowledge of demographic distribution and analysis of clinical profile from this study would help for patient management of COVID-19 till the invention of specific drug and vaccines. We aimed to analyze the clinical profile of fist 100 cases of COVID-19 admitted in a teaching hospital. Methods: In this observational study, RT-PCR confirmed first 100 hospitalized COVID-19 cases, admitted in Mugda Medical College Hospital were included. With well informed consent, a structured questionnaire was fulfilled during the time of hospital stay. Data were analyzed with clinical outcome, hospital stay, clinical staging and comorbidity of admitted patient from 20th March to 10th April. Results: Among the total participants, male were predominate (59%). Age groups were ranging from 9 to 80 years and mean age was 43 years. Common symptoms were fever (91%), cough (33%), dyspnea (41%), sore throat (12%), diarrhea (12%) and myalgia (2%). Mild cases (53%) were common, followed by moderate (31%), severe (13%) and critical (3%). Average hospital stay was 11 days. Common comorbidities were diabetes mellitus (21%), hypertension (17%), chronic kidney disease (11%), bronchial asthma (8%), stroke (3%) and ischaemic heart disease (2%). Conclusion: Distinct demographic presentation with age variability, clinical presentation with variable fatality in different countries may help the further steps taken by the policymaker of low resource country for the prevention of infection and management of COVID-19. Birdem Med J 2020; 10, COVID Supplement: 18-22

Background The impact of vitamin D on COVID-19 infection has been much discussed recently. Our aim was to evaluate the association between baseline serum 25(OH)D with severity of COVID-19. Method This was an prospective study, where 174 COVID- 19 in-patients of an academic hospital in an urban setting were enrolled from Aug, 2020 to Oct, 2020. After detailed clinical history taking and examination, patients were divided into mild, moderate, severe and critical categories. Vitamin D level was measured. Relation between level of vitamin D and disease severity was determined. Result Mean age of the study population was 52.01 years. 13% mild, 22.99% moderate, 26.44% severe and 3.45% were critical cases. 76% of the patients had vitamin D deficiency. No statistical significance between the level of vitamin D and disease severity was seen (p= 0.430). Conclusion Our study revealed there is no correlation between vitamin D deficiency and severity of COVID-19. J Bangladesh Coll Phys Surg 2022; 40: 166-170