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Silver nanoparticles (AgNPs) can be used to treat many clinical challenges due to their resourceful medicinal properties present in them. Moreover, AgNPs exhibits unique optoelectronic properties, distinct chemistry, high surface-to-volume ratio, and high avidity, making them principally suitable for healthcare applications. In the present perspective, size and shape-based AgNPs antimicrobial action are reviewed. Furthermore, the intrinsic features and plausible toxicity of AgNPs with emerging applications across daily life and healthcare categories are discussed. This perspective urges researchers to focus on the hazards of AgNPs before their utilization to deal with human diseases. Moreover, additional studies have been suggested concerning the sustainable engineering of nanoparticles toward safety and quality in human health complications. All these concerns are still considered a challenge because nanoparticle characterization is still in its infancy for implementation in human life. Finally, this perspective provides a scientific foundation for the construction of global accord guidelines in the future.

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