Environmentally amiable biogenic strategy for in‐situ one‐step synthesis of Pd‐NPs decorated on carbon nanotubes (CNTs) and its synthetic utility for C−H activation of benzamides to access isoquinolones has been reported for the first time. The phytochemicals present in Gliricidia sepium leaves extract was found to be serve as a reducing agent to reduce Pd (II) to Pd (0) and subsequently acts as a stabilizing agent. The formation of Pd@CNTs was confirmed by P‐XRD, FE‐SEM, EDX and ICP‐OES analysis technique with active Pd content 42.82 % w/w. In addition, DFT study of phytochemicals found in Gliricidia sepium leaves extract were conducted. The catalytic activity was showcased for the cost‐effective, step and atom economic synthesis of isoquinolones via C−H and N−H bond activation without the aid of external ligands. A series of isoquinolone derivatives were synthesized in good to excellent yields under air as a sole oxidant. In addition, catalyst recyclability and mechanistic experiments were deliberated. The Pd@CNTs unveiled superior catalytic activity and high durability towards hydrogen evolution reaction in acidic media. The Pd@CNTs attains the current density of 10 mA/cm2 at an over potential of 127 mV with a small Tafel slope of 41 mV/dec.

The plants are enormous source of medicinally important ingredients. The separation of active plants compounds leads to discovery of many drugs derived directly from plants. In the current study, The HPLC analysis is carried for the methanolic extracts of gives different peaks at 254 nm, it may be alcoholic compound. The FTIR spectrum confirmed the presence of alcohol, alkanes, carboxylic acid, aromatics, esters and ethers in methanolic extract of Sonneratia apetala. UV-Visible profile showed different peaks ranging from 200-800 nm with different absorption respectively. In silico study, especially physicochemical properties, lipophilicity, water solubility, pharmacokinetics, drug likeness and medicinal chemistry performed by using the Swiss ADME online tool.

Phytochemicals are biologically active compounds found in plants. Phytochemicals of medicinal plant can cure various diseases thus phytochemical screening of plants is necessary for the discovery and devlopment of therapeutic agents. In present study. The FTIR spectrum of crude extract confirmed the presence of alkanes, carboxylic acid, alcohol, aromatics and esters. The HPLC analysis of methanolic extract shows 11 peaks at 254nm, it may be phenolic and alcoholic compounds. The plant extract was scanned by using UV-VIS spectrophotometer ranging from 200-700nm and characteristic peaks were detected with different absorption respectively. The ADME study particularly focuses on important properties like lipophilicity, water solubility, pharmacokinetic, drug likeness, medicinal chemistry and this study carried out by using insilico ADME tool called Swiss ADME.

We have explored the ADME (Absorption, Distribution, Metabolism and Excretion) profile of eight different derivatives of tetrasubstitutedaza-dipyrrins. Compound 1-9 are screened with the help of onlinewebtoolSwissADME. Studies were performed for pharmacokinetic, lipophilicity, water solubility, bioavailability and drug likeness properties. Compound 9 found to a optimum among all the compounds under investigation.