In this research paper, blockchain-based trust management model is proposed to enhance trust relationship among beacon nodes and to eradicate malicious nodes in Wireless Sensor Networks (WSNs). This composite trust evaluation involves behavioral-based trust as well as data-based trust. Various metrics such as closeness, honesty, intimacy and frequency of interaction are taken into account to compute behavioral-based trust of beacon nodes. Further, the composite (behavior and data) trust value of each beacon nodes is broadcast to Base Stations (BS) to generate a blockchain of trust values. Subsequently, the management model discards the beacon node with least trust value and that ensures reliability and consistency of localization in WSNs. The simulated results of the proposed algorithm are compared with the existing ones in terms of detection accuracy, False Positive Rate (FPR) and False Negative Rate (FNR) and Average Energy Consumption (AEC).

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Increased cranial pressure due to development of edema contributes significantly to the pathology of traumatic brain injury (TBI). Induction of an astrocytic water channel protein, Aquaporin 4 (AQP4), is known to predominantly contribute to cytotoxic edema following TBI. However, the mechanism for the increase in AQP4 following 24 h of TBI is poorly understood. Here we show that transcriptional activation of a ubiquitously expressed mammalian forkhead transcription factor, Foxo3a, induces cerebral edema by increasing the AQP4 level in the controlled cortical impact model of TBI in mice. TBI stimulates nuclear translocation of Foxo3a in astrocytes and subsequently augments its binding to AQP4 promoter in pericontusional cortex. Nuclear accumulation of Foxo3a is augmented by a decrease in phosphorylation at its Ser256 residue due to inactivation of Akt after TBI. Depletion of Foxo3a in mice rescues cytotoxic edema by preventing induction of AQP4 as well as attenuates memory impairment after TBI in mice.

A distributed and transparent ledger system is considered for various e-commerce products including health medicines, electronics, security appliances, food products and many more to ensure technological and e-commerce sustainability. This solution, named as 'PRODCHAIN', is a generic blockchain framework with lattice-based cryptographic processes for reducing the complexity for tracing the ecommerce products. Moreover, we have introduced a rating based consensus process called Proof of Accomplishment (PoA). The solution has been analyzed and experimental studies are performed on Ethereum network. The results are discussed in terms of latency and throughput which prove the efficiency of PRODCHAIN in e-commerce products and services.The presented solution is beneficial for improving the traceability of the products ensuring the social and financial sustainability. This work will help the researchers to gain knowledge about the blockchain implications for supply chain possibilities in future developments for society.