Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre-operative SARS-CoV-2 infection were compared with those without previous SARS-CoV-2 infection. The primary outcome measure was 30-day postoperative mortality. Logistic regression models were used to calculate adjusted 30-day mortality rates stratified by time from diagnosis of SARS-CoV-2 infection to surgery. Among 140,231 patients (116 countries), 3127 patients (2.2%) had a pre-operative SARS-CoV-2 diagnosis. Adjusted 30-day mortality in patients without SARS-CoV-2 infection was 1.5% (95%CI 1.4-1.5). In patients with a pre-operative SARS-CoV-2 diagnosis, mortality was increased in patients having surgery within 0-2 weeks, 3-4 weeks and 5-6 weeks of the diagnosis (odds ratio (95%CI) 4.1 (3.3-4.8), 3.9 (2.6-5.1) and 3.6 (2.0-5.2), respectively). Surgery performed ≥ 7 weeks after SARS-CoV-2 diagnosis was associated with a similar mortality risk to baseline (odds ratio (95%CI) 1.5 (0.9-2.1)). After a ≥ 7 week delay in undertaking surgery following SARS-CoV-2 infection, patients with ongoing symptoms had a higher mortality than patients whose symptoms had resolved or who had been asymptomatic (6.0% (95%CI 3.2-8.7) vs. 2.4% (95%CI 1.4-3.4) vs. 1.3% (95%CI 0.6-2.0), respectively). Where possible, surgery should be delayed for at least 7 weeks following SARS-CoV-2 infection. Patients with ongoing symptoms ≥ 7 weeks from diagnosis may benefit from further delay.

SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery); recent (1-6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2; 2.2% (50/2317) in patients with peri-operative SARS-CoV-2; 1.6% (15/953) in patients with recent SARS-CoV-2; and 1.0% (11/1148) in patients with previous SARS-CoV-2. After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1-2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2-3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9-3.0)). Overall, venous thromboembolism was independently associated with 30-day mortality ). In patients with SARS-CoV-2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri-operative or recent SARS-CoV-2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS-CoV-2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly.

Background: Optimum and good quality of sleep are pertinent to the health and equilibrium of biological functions. Increased use of electronic gadgets for academics and social interactions during the COVID-19 pandemic has extended the screen time of students, affecting sleep and eating patterns. Aim & Objective: To study the association of extended screen time on sleep pattern and calorie intake among college students during the COVID-19 pandemic. Settings and Design: Observational study was conducted using ‘Google forms’ to collect data on sleep and food intake among 60 college-going students. Methods and Material: Google form composed of questions related to demographic, anthropometry, screen time, sleep quality (PSQI) & dietary pattern (food frequency questionnaire) and tied to written consent was sent via WhatsApp to college students. Statistical analysis used: Data were grouped based on the screen time >10 hrs and </=10 hrs/day. Independent “t” test, Chi-square test and Mann Whitney test were used to compare the sleep domains scores and calorie intake. Results: With an average screen time of 10.9 hrs, 38% of students were using the screen maximally during the night. Poor Sleep Quality was (PSQI Score>5) observed in 80% of the college students, with 46.6% having a sleep of <5 hrs/day. Students' calorie intake was ten times the recommended daily requirement during the stay at home but was negatively related to screen-time, though non-significant. Conclusions: The study concludes that average screen time of students of age group 18-24 years have increased during night under the lockdown. This extended viewing in night has shifted the sleep circadian cycle to morning hours, with daytime sleepiness and poor sleep quality. The high calorie intake was also observed in students during lockdown though no correlation was established with the screen time and sleep quality.

Background Plant diseases significantly affect the crop, so their identification is very important. Correct identification of these diseases is crucial for establishing a good disease control strategy to avoid time and financial losses. In general, machines can greatly reduce the possibility of human error. In particular, computer vision techniques developed through deep learning have paved a way to detect and diagnose these plant diseases on the leaf. Methods In this work, the model AFD-Net was developed to detect and identify various leaf diseases in apple trees. The dataset is from Kaggle 2020 and 2021 and was financially supported by the Cornell Initiative for Digital Agriculture. An AFD-Net was proposed for leaf disease classification in apple trees and the results of the efficiency of the model are compared with other state-of-the-art deep learning approaches. Results The results of the experiments in the validation dataset show that the proposed AFD-Net model achieves the highest values of 98.7% accuracy for Plant Pathology 2020 and 92.6% for Plant Pathology 2021 compared to other deep learning models in the original and extended datasets. Discussion The results also indicate the efficiency of the proposed model in identifying leaf diseases on apple trees for major and minor classes, i.e., for multiple classification.

The paper investigates the spread pattern and dynamics of Covid-19 propagation based on SIR model. Using the model dynamics, an analytical estimation has been obtained for virus span, its longevity, growing pattern, etc. Experimental simulations are carried out on the data of four regions of India over a period of two months of country-wide lockdown. The analysis illustrates the effect of lockdown on the contact rate and its implication. Simulation results illustrate that there is a cut-down in effective contact rate by a considerable factor ranging from 2 to 4 for the selected regions. Further, the estimates for the vaccines to be developed, maximum range and span of the disease can be also estimated. Results portray that the SIR model is a significant tool to cast the dynamics and predictions of Covid-19 outbreak in comparison to other epidemic models. The study demonstrates the progression of real time data in accordance with the SIR model with high accuracy.