It is assessed that about 3.6 billion individuals are in danger, while roughly 50 million to 200 million dengue diseases, 500,000 extreme dengue cases and more than 20,000 dengue related passing's happen every year. Dengue viral contaminations are a standout amongst the most essential mosquito borne sicknesses on the planet. The dengue infections are certain stranded RNA infections in the sort Flavivirus, family Flaviviridae Dengue is transmitted in people by two types of Aedes mosquitoes to be specific, Aedes aegypti and Aedes albopictus. No immunization is accessible for anticipating this ailment, different medicines are being explored. This illness is the wellspring of a substantial number of passing's. Homeopathic meds, home grown meds and home solutions for dengue are normal, unadulterated, have no reactions and are additionally incredibly successful and also animate the insusceptible arrangement of patient. The medicinal specialists which are observed to be effective in such manner are papaya, Methi leaves, leaves of Neem tree, Carapichea, Vitamin C riched organic products (Embellica, Psidium guajava, Carica papaya), coriander, Ledum, Ocimum basil, grain grass, Carapichea and Echinacea and so forth. Because of simple accessibility, minimal effort and high affectivity, text product these normal and home grown cures are prescribed to dengue patients to fix the sickness.

New controlled transdermal drug delivery systems (TDDS) technologies (electrically-based, structure-based and velocity-based) have been developed and commercialized for the transdermal delivery of troublesome drugs. The use of solvents that affect the skin barrier function is one of the classic strategies of penetration enhancement. The liposomes as a delivery system for hydrophobic and hydrophilic drugs is well recognized Standardized poly(ethylene glycol)modified (PEGylated) liposomes, which have been widely used in research as well as in pre-clinical and clinical studies. The aim of present work was to investigate the potential utility of novel carrier gel core liposomes. This delivery system is capable of transporting the drug or macromolecules painlessly through skin into the blood circulation at fixed rate. The study includes the development of liposomal and ethosomal gels for transdermal delivery to overcome the side effects associated with oral route and comparing the latest gel-core liposomes (hyaluosomes) with non-conventional liposomal systems such as propylene glycol (PG)-liposomes, ethosomes, transferosomes and conventional liposomes. With the advancement in liposomal sciences, it warrants that hyaluosomes as a promising transdermal liposomal system for favourable rheological characteristics as well as superior transdermal permeation that proved greater capacity than conventional and other non-conventional liposomal systems.