Patient prognosis is a critical consideration in the treatment decision-making process. Conventionally, patient outcome is related to tumor characteristics, the cancer spread, and the patients’ conditions. However, unexplained differences in survival time are often observed, even among patients with similar clinical and molecular tumor traits. This study investigated how inflammatory radiomic features can correlate with evidence-based biological analyses to provide translated value in assessing clinical outcomes in patients with NSCLC. We analyzed a group of 15 patients with stage I NSCLC who showed extremely different OS outcomes despite apparently harboring the same tumor characteristics. We thus analyzed the inflammatory levels in their tumor microenvironment (TME) either biologically or radiologically, focusing our attention on the NLRP3 cancer-dependent inflammasome pathway. We determined an NLRP3-dependent peritumoral inflammatory status correlated with the outcome of NSCLC patients, with markedly increased OS in those patients with a low rate of NLRP3 activation. We consistently extracted specific radiomic signatures that perfectly discriminated patients’ inflammatory levels and, therefore, their clinical outcomes. We developed and validated a radiomic model unleashing quantitative inflammatory features from CT images with an excellent performance to predict the evolution pattern of NSCLC tumors for a personalized and accelerated patient management in a non-invasive way.

O objetivo deste artigo é mostrar como Alexandre Kojève, através de um Hegelo-Marxismo decididamente heterodoxo, tentou tematizar uma forma de dualismo ontológico que poderia ser baseada em um materialismo ao mesmo tempo ‘dualista’ e essencialmente ‘indeterminista’. Para este fim, divido meu ensaio em três partes. Na primeira, veremos como Kojève tentou redefinir os pressupostos ‘ontológicos’ do pensamento tanto do Hegel quanto do de Marx; na segunda parte, focalizarei o projeto de Kojève de mise à jour do hegelianismo também à luz das novas descobertas da física quântica; na terceira e última parte, tentarei fazer emergir, de forma crítica, alguns aspectos puramente aporéticos das teorias de Kojève.

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