Many pharmaceutical molecules have solubility problems that until yet consist a hurdle that restricts their use in the pharmaceutical preparations. Lacidipine (LCDP) is a calcium-channel blocker with low aqueous solubility and bioavailability.         Lipid dosage forms are attractive delivery systems for such hydrophobic drug molecules. Nanoemulsion (NE)  is one of the popular methods that has been used to solve the solubility problems of many drugs. LCDP was formulated as a NE utilizing triacetin as an oil phase, tween 80 and tween 60 as a surfactant and ethanol as a co-surfactant. Nine formulas were prepared, and different tests performed to ensure the stability of the NEs, such as thermodynamic stability, particle size, Polydispersity index, zeta potential, dye solubility test, dilution test, drug content test and in-vitro drug release. Results of characterization showed that LCDP NE (F-5) with (oil: Smix (3:1):DDW (10:60:30)) ratio was selected as a best formula, since it have excellent thermodynamic stability with a particle size of 13.42, low PDI 0.234 , zeta potential (-14.5mV), efficient electrical    conductivity  0.241ms/cm , good pH value (5.9), good percent of light transmittance (99.10%) , with  acceptable viscosity , higher percent of drug content (99.14%) and complete release of the drug after (30 min.) with significantly higher (P<0.05)   dissolution rate in comparison with pure drug powder.      From the results obtained NE was found to be an efficient method to enhance the solubility and dissolution rate of drugs that have poor water solubility (lipophilic drugs).    

Diclofenac sodium is a non steroidal anti-inflammatory agent used in the treatment of many diseases including rheumatoid arthritis and ankylosing spondylitis . This investigation concerned with the preparation and evaluation of diclofenac sodium as conventional suppositories to achieve optimum drug release at a rectal route.The influence of suppository base type on the in vitro release of the drug and the physical properties was studied using various hydrophilic and lipophilic bases in the preparation of conventional type suppositories. Moreover the influence of storage time and storage temperature was investigated. One formula with optimum and uniform release profile were selected and stored at 4°C and 25°C for 1, 15, 30, 45 days.The result revealed that the effect of storage of suppositories prepared from polyethylene glycol base was found to cause decrease in the melting time, hardness and slight increase in the release rate because of the brittleness of these bases, while the storage of the suppositories prepared from Witepsol bases cause a slight increase in the softening time, melting time and hardness, as well as decrease in the percent of the drug release.