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Purpose: To assess the role of dietary factors in the development of diabetic retinopathy (DR) in diabetics. Methods: This prospective study was carried out on patients attending the outpatient department of ophthalmology for a period of 1 year. An interview-based 24-hour diet recall was used to document average daily dietary nutrient intakes. Each patient was subjected to a comprehensive ocular examination to look for DR. Results: A total of 261 patients attending the outpatient department of ophthalmology were the participants for this study. The mean (±SD) age of the participants was 57.73 ± 11.29 years, and 67% were men. One hundred and six participants had DR. Univariate analysis revealed sex, duration, fish (times/week), egg (yes/no), rice lunch (yes/no), rice dinner, rice (boiled/white), and total calorie intake to be associated with DR ( P < 0.05). Logistic regression multivariable analysis revealed males (OR: 3.20, 95% CI: 1.65–6.19), longer duration of diabetes (OR:1.05,95% CI:1.01-1.11), antioxidant intake (OR: 3.42, 95% CI: 1.65–7.05), and consumption of rice (OR: 3.19, 95% CI: 1.17–8.69) to have significant association with DR ( P < 0.05), with the odds of developing DR increasing three times in these patients. The odds of developing DR were lesser with more frequent (>2 times/week) fish consumption (OR: 0.42, 95% CI: 0.18–0.94) and in patients on pharmacological treatment for diabetes mellitus (OR: 0.16, 95% CI: 0.04–0.58). Binary logistic regression revealed chapathi consumption (OR: 9.37, 95% CI: 1.64–53.68) to be associated with severe forms and fish consumption (OR: 0.06, 95% CI: 0.01–1.06) ( P < 0.05) to be associated with less severe forms of DR. Conclusion: Males, longer duration of diabetes, antioxidant intake, fish consumption, and consumption of rice were associated with the occurrence of DR. Participants with diabetes who consumed fish more frequently and those who were on pharmacological treatment for diabetes mellitus had a significantly lower risk of DR and frequent fish consumption could reduce the risk of DR progression.

The objective of this meta-analysis was to evaluate the effect of prostaglandin analogues (PGA) on central corneal thickness (CCT) in patients with glaucoma. Key electronic databases were searched for randomized controlled trials (RCTs) involving the CCT effects of prostaglandin use for glaucoma. Primary outcome measures were the mean difference in the CCT measurement from baseline to the last available assessment. Intraocular pressure and other corneal changes were recorded as secondary. Efficacy estimates were measured by their weighted mean difference (WMD) with 95% confidence intervals (CI’s) by using the random-effects model for primary and secondary outcomes Trial sequential analysis was used to determine if the current evidence was sufficient and conclusive. Eight RCTs met our inclusion criteria. A total of 879 patients were included. The overall effect showed that PGA’s had a significant CCT lowering effect (WMD = −7.04, 95%CI: −10.07 to −4.00, P < 0.00001). We pooled results of 5 RCT’s on Travoprost (WMD = −10.44, 95%CI: −16.80 to −4.08, P = 0.001), seven trials on Latanoprost (WMD = −4.73, 95% CI: −9.70 to 0.25, P = 0.06), and three trials on Bimatoprost (WMD = −11.88, 95%CI: −21.03 to −2.73, P = 0.01). The WMD across groups in >6 months of PGA use was −11.37 (95%CI: −17.17 to −5.58, P = 0.0001), and in <6 months of PGAs group was −8.35 (95% CI: −12.01 to −4.69, P < 0.00001), suggesting a longitudinal effect of PGAs on CCT. In conclusion, Bimatoprost and Travoprost caused a statistically significant reduction in the thickness of central cornea. Though only a few studies were included, the narrow confidence intervals and adequate sample size suggest that these findings are valid.

Context:Eyelashes play an important role in one's personality and builds confidence. Now-a- days, mascaras are used very commonly as an eye cosmetic. Mascara induced loss of eyelashes has been evaluated in this study.Aim:The aim of this study is to determine the effect of mascara on eyelashes and to find an association between the usage of mascara and fall of eyelashes.Settings and Design:Cross-sectional questionnaire based study done on medical students.Subjects and Methods:Medical students were interviewed with a semi-structured questionnaire on mascara usage.Statistical Analysis:MedCalc 9.3.6.0 version.Results:A total of 128 medical students who used mascara were included in this study. Mean (standard deviation) age of the students was 23.7 ± 2.0 years. Nearly 31% of the subjects faced the eye problems. Eyelash fall was observed in 19%. Higher mean years of use of mascara (5.17 ± 3.8 vs. 3.19 ± 2.6, P = 0.027, t-test) influenced the fall of eyelashes in the subjects. Itching of the eye prior to fall of eyelashes was observed in all subjects (P = 0.0002, Fisher exact test). A higher percentage of eyelash falls was observed in subjects who used water for removal of waterproof mascara (27%).Conclusion:There is a significant positive association between long-term use of eye cosmetics like mascara and fall of eyelashes. Furthermore, use of water for removal of waterproof mascara was associated with a higher incidence of eyelash fall.