No abstract

No abstract

Background and Objective: The causal role of maternal nutrition in orofacial clefts is uncertain. We tested hypotheses that low maternal vitamin B12 and low folate status are each associated with an increased risk of isolated cleft lip with or without cleft palate (CL±P) in a case–control study in Tamil Nadu state, India. Methods: Case-mothers of CL±P children (n = 47) and control-mothers of unaffected children (n = 50) were recruited an average of 1.4 years after birth of the index child and plasma vitamin B12, methylmalonic acid (MMA), total homocysteine (tHcy), and folate were measured at that time. Logistic regression analyses estimated associations between nutrient biomarkers and case–control status. Results: Odds ratios (ORs) contrasting biomarker levels showed associations between case-mothers and low versus high plasma vitamin B12 (OR = 2.48, 95% CI, 1.02-6.01) and high versus low plasma MMA, an indicator of poor B12 status (OR = 3.65 95% CI, 1.21-11.05). Case–control status was not consistently associated with folate or tHcy levels. Low vitamin B12 status, when defined by a combination of both plasma vitamin B12 and MMA levels, had an even stronger association with case-mothers (OR = 6.54, 95% CI, 1.33-32.09). Conclusions: Mothers of CL±P children in southern India were 6.5 times more likely to have poor vitamin B12 status, defined by multiple biomarkers, compared to control-mothers. Further studies in populations with diverse nutritional backgrounds are required to determine whether poor maternal vitamin B12 or folate levels or their interactions are causally related to CL±P.

No abstract

Introduction: Coronavirus has spread havoc globally, resulting in the closure of all sectors including education. Therefore, to continue a child’s learning, the government started online classes from home by involving parents. This new learning method might be hectic and challenging for parents; therefore, this study aimed to assess the perception, burden, and satisfaction of parents of children attending online classes. Methods: A cross-sectional online survey was conducted in three schools of Rishikesh, Uttarakhand. A total of 220 parents of children attending online classes and studying between first and fifth standard responded voluntarily. Google Form was used to assess perception, burden, and satisfaction regarding online classes and analyzed using descriptive and inferential statistics. Results: The mean age of parents was 34.1 ± 5 years, and most of the respondents were mothers. Out of 220 parents, 52% showed negative perception, 42% experienced moderate to severe burden, and 51% were highly satisfied with the online classes during COVID-19 lockdown. Pearson’s correlation coefficient showed a positive correlation between perception andsatisfaction of parents (P = 0.000, r = 0.616 *). Parental role and preferred teaching method had a significant association with parental perception (P < 0.01, P < 0.05). The app used and preferred teaching method during the pandemic had a significant association with parental satisfaction regarding online classes (p < 0.01, P < 0.05). Conclusion: Parents had negative perception and experienced moderate to severe burden concerning online classes. At the same time, they were highly satisfied with achieving educational objectives to some extent during the COVID-19 pandemic.