Introduction:Rabeprazole, a member of substituted benzimidazoles, inhibits the final step in gastric acid secretions. This drug claims to cause fastest acid separation (due to higher pKa), and more rapidly converts to the active species to aid gastric mucin synthesis. The most significant pharmacological action of Rabeprazole is dose dependent suppression of gastric acid secretion; without anticholinergic or H2-blocking action. It completely abolishes the hydrochloric acid secretion as it is powerful inhibitor of gastric acid. Rabeprazole is acid labile and hence commonly formulated as an enteric coated tablet. The absorption of rabeprazole occurs rapidly as soon as tablet leaves the stomach.Aim:In the present study an attempt was made to formulate and evaluate Rabeprazole sustained release matrix tablet using wet granulation technique incorporating various polymers like HPMC-E15, Carbopol934, and sodium carboxymethyl cellulose (CMC).Materials and Methods:The Formulated tablets were evaluated for different physicochemical properties like rheological properties, weight variation, thickness, hardness, % friability, in vitro release studies and drug content.Results:Studies revealed that all the physicochemical parameters comply with the official standards. The in vitro release studies exhibits the release up to 90%, over a prolonged period of time which confirms the extended release profile of formulation, having better bioavailability as well as decreased dosing frequency with reduced doses.Conclusion:The sustained release matrix tablets of rabiprazole shown better bioavailability, efficacy and potency, when compared with official standards.

Novel drug delivery system (NDDS) is an innovative approach to drug delivery that addresses the limitations of the traditional drug delivery systems. If the novel drug delivery system is applied in herbal drugs, it should facilitate in increasing the efficaciousness and reducing the side effects of various herbs. This is often the essential plan behind incorporating novel technique of drug delivery in herb compounds. So it's necessary to integrate novel drug delivery system and Indian Ayurvedic medicines to conflict additional serious diseases. For a long time herb medicines weren't considered for development as new formulations because of lack of scientific justification and process difficulties such as standardization, extraction and identification, purification of individual drug elements or phyto-constituents in advanced polyherbal systems. The on the market approaches for novel herb analysis will solve the scientific wants (such as determination of pharmacokinetics, mechanism and site of action, correct dose needed etc.) of herbal medicines to be incorporated in novel drug delivery system. Phytosomes are proprietary method developed by Indena, to include phospholipids into standardized extracts and then greatly improve their absorption and utilization. Phytosomes loaded are advanced herbal products made by binding individual part of herb or plant extract to phosphatidylcholine leading to a product that's higher absorbed and produces higher results than the traditional herbal extracts.

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In this present study, diethyl phenyl acetamide (DEPA), a multi-insect repellent, was entrapped in a hydrophilic biodegradable polymer calcium alginate to increase its efficacy. For encapsulation, an emulsion technique followed by gelation method was adopted. Various characterizations of the formed DEPA-containing alginate microcapsules were carried out. Using UV-Vis spectrophotometer the k max of DEPA observed was at 259 nm. The particle size distribution of the encapsulated material was carried out by a dynamic light scattering (DLS) method and the mean diameter observed was (500 AE 50) nm. The entrapment of DEPA in the encapsulated material was confirmed by FTIR. The surface morphology, size, and shape of the encapsulated material was analyzed using atomic force microscopy (AFM), which showed encapsulated bead size around 250 nm with uniform distribution. The percentage entrapment of DEPA in the encapsulated samples was about (70 AE 5)%. A slow release study of DEPA from the encapsulated biopolymer (alginate) in isopropyl alcohol was also carried out, which showed continuous release up to five hours.

The aim of present study was to design and evaluate an elementary osmotic pump-based drug delivery system for controlled release of metformin and glipizide simultaneously for treatment of type II noninsulin dependent diabetes mellitus. Inclusion complex of glipizide with β- cyclodextrin was prepared to enhance its solubility. Core tablets were prepared by wet granulation method. Effects of different variables like amount of plasticizer, osmogen, orifice size and dissolution media were studied on release profile for both drugs. Morphology of semi permeable was studied using electron microscope before and after dissolution test. On increasing the amount of osmogen, the release of both drugs was found to be increased. No significant effect of PVP K 30 was observed on drug release. Optimization results indicated that the release of both drugs was directly proportional to the surface porosity of the membrane. It was concluded that the osmotic pump tablets could provide more prolonged and controlled release that may result in an improved therapeutic efficacy and patient compliance.