Background: Diabetes is a metabolic disease which affects various organs of the body like heart, eye, kidney, skin and peripheral nerves. Diabetic cardiomyopathy is defined as the appearance of the symptoms of Congestive heart failure in diabetic patient in the absence of hypertension and any structural or congenital heart disease. The aim of the study is to find the relation between type 2 diabetes mellitus and cardiomyopathy, highlighting the variation in incidence according to age, sex and severity on basis of Doppler echocardiographic diagnosis. Methods: The prospective study was conducted for the duration of one year on 100 newly diagnosed Type 2 Diabetes patients aged between 30-60 years. Doppler echocardiography and HbA1c level of the patients was done. The study was conducted on the basis of grading of diastolic dysfunction on echocardiography. Quantitative data was analysed with the help of 't' test and qualitative data with the ChiSquare and Fisher Exact Test. Statistical significance was taken as P < 0.05. Results: In this study, 39% of the newly diagnosed type 2 diabetes mellitus patients developed diabetic cardiomyopathy. In females, the disease was statistically absent in more patients (35) as compared to males (26) (<0.05). The commonest age group affected by grade 1 disease was 41-50 years. The incidence of grade 2 disease was more in age group 51-60 years. The grade 1 diabetic cardiomyopathy was statistically more common in males as compared to females (<0.05). The grade 2 diabetic cardiomyopathy was more common in females, but was statistically insignificant. Patients with HbA1c <8 have 16% chances to get LVDD with significant P value of 0.02. Patients with HbA1c between 8 to 10 have 30% chances to get LVDD with significant P value of 0.01. Conclusion: Diabetic cardiomyopathy is an important complication of type 2 diabetes mellitus patient. HbA1c level and Doppler echocardiography plays an important role in estimating the prevalence and severity of diabetic cardiomyopathy.

Background: Many studies have shown that high circulating uric acid (UA) levels lead to both hypertension and cardiovascular complications, leading to poor patient prognosis. People with metabolic syndrome (MetS), which is closely linked to hypertension, also tend to have high SUA levels. SUA levels elevate due to metS and hypertension share common pathophysiological features, so it has been difficult to confirm their involvement in the pathogenesis of hypertension. Therefore, the aim of this present study is to find out the association between the uric acid and blood pressure levels in both male and female patients of different age groups. Methods: It was 18 months, single-centered, cross-sectional study, conducted in the department of General Medicine, at National institute of medical sciences and research hospital. Blood samples were collected from 140 participants of both genders attending the department of Medicine with hypertensive and pre-hypertensive stages to analyze serum uric acid (SUA) level and lipid profile. The potential relationship between SUA and BP was assessed by descriptive statistics for analyzing quartiles and odd ratio. Results: Among 140 hypertensive patients, 66 of them were in the 61-80 age groups. Twenty percent of patients were under the age of 20 and one percent was over 87 years of age. 40 patients with pre-hypertension, 28 (70%) of patients having elevated SUA level, while 100 of patients with hypertension, 59(59%) of having elevated SUA level. It had also been found that the diagnosis duration of hypertension and hyperuricemia was causing the elevation of SUA levels in the patients. Conclusion: The present study indicates a direct relationship between SUA levels and hypertension. SUA levels were quite a bit higher in patients with hypertension in contrast to those with pre-hypertension, suggesting the severity of hypertension related to SUA levels.

Background: Cardiovascular diseases (CVD) are the commonest cause of mortality and morbidity worldwide. Despite the rising proportions of CAD, only limited data are available on the relationship between Vitamin D. This study was aimed to assess the serum levels of 25(OH) Vitamin D and its causal association of Vitamin D deficiency as an independent risk factor in patients with Acute ST-Elevation Myocardial Infarction in National Institute of Medical Sciences and Research, Jaipur, Rajasthan. Material and Methods: Patients admitted with acute ST- Elevation and NON-ST- Elevation Myocardial Infarction in the CCU unit of the National Institute of Medical Science & Research, Jaipur were chosen as cases. Rest healthy same age and sex-match ambulatory subjects were kept as controls. The data entered in the MS EXCEL spreadsheet and analysis will be done using Statistical Package for Social Sciences (SPSS) version 23.0. Continuous variables were presented as mean ± SD. Categorical variables were expressed as frequencies and percentages. The Chi-square test of association or Fischer exact test has been used to determine if there is an association between two categorical variables. Results: Among 50 study cases, the prevalent age group where 50-60 years was 16(32%) followed by 40-50 years (28%) while in control the majority of the participants were in between 40-50 years, 16(32%) followed by 15 cases (30%) in 30-40 years. It was observed that the mean BMI of the study cases was 29.11 ± 3.1 and for controls was 24.41 ± 1.92. Fifty-four percent of cases were found overweight with a BMI range between 25-29.9 and 21(42%) were found obese. In considering the control group, 21(42%) subjects were found overweight with a BMI range between 25-29.9 while no subject was obese with above 30. Most of the cases with vitamin deficiency and vitamin insufficiency were either overweight or obese and had BMI above 25 and a statistically significant difference with p=0.02828. ......