Head and Neck Squamous Cell Carcinoma (HNSCC) is a relatively uncommon malignancy due to the human papillomavirus or environmental factors such as excessive alcohol or tobacco use. Its most common metastatic locations are the lungs, bone, and liver. We are reporting a much more exceedingly rare site, a percutaneous endoscopic gastrostomy (PEG) site. HNSCC metastases and recurrences are commonly seen; however, they present complex challenges to manage successfully. Our presenting patient had an initial diagnosis of hypopharyngeal squamous cell carcinoma and then developed an isolated metachronous metastatic tumor at the site of his gastrostomy tract approximately one year later.

Liposarcoma is a locally aggressive tumor that may originate in soft tissue sites such as the retroperitoneum or the extremities, or less frequently, from the bone. The fatty tumor may have an insidious growth pattern and be present incidentally on imaging, or it may be present with symptoms such as small bowel or ureter obstruction. The diagnosis can be confirmed post-operatively via fluorescence in situ hybridization (FISH) with the presence of mouse double minute 2 (MDM2) homolog protein and cyclin-dependent kinase 4 (CDK4) gene amplification. The rate of recurrence may be high depending on the subtype of liposarcoma, so it is always recommended to have the patient undergo routine imaging every six months to a year. In this case report, we present a patient who presented with a massive, incidental liposarcoma found on imaging after coming to the emergency department for lower extremity trauma.