The authors have developed a registration framework for mapping in vivo MRI data of the prostate with histology by implementing a number of processing steps and ex vivo MRI of the prostate specimen. Validation of DIR was challenging, particularly in prostates with few or mostly linear rather than spherical shaped features. Refinement of their MR imaging protocols to improve the data quality is currently underway which may improve registration accuracy. Additional mpMRI sequences will be registered within this framework to quantify prostate tumor location and biology.

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A major problem in designing vaccine for the dengue virus has been the high antigenic variability in the envelope protein of different virus strains. In this study, a computational approach was adopted to identify a multi-epitope vaccine candidate against dengue virus that may be suitable for large populations in the dengue-endemic regions. Different bioinformatics tools were exploited that helped the identification of a conserved immunological hot-spot in the dengue envelope protein. The tools also rendered the prediction of immunogenicity and population coverage to the proposed 'in silico' vaccine candidate against dengue. A peptide region, spanning 19 amino acids, was identified in the envelope protein which found to be conserved in all four types of dengue viruses. Ten proteasomal cleavage sites were identified within the 19-mer conserved peptide sequence and a total of 8 overlapping putative cytotoxic T cell (CTL) epitopes were identified. The immunogenicity of these epitopes was evaluated in terms of their binding affinities to and dissociation half-time from respective human leukocyte antigen (HLA) molecules. The HLA allele frequencies were studied among populations in the dengue endemic regions and compared with respect to HLA restriction patterns of the overlapping epitopes. The cumulative population coverage for these epitopes as vaccine candidates was high ranging from approximately 80% to 92%. Structural analysis suggested that a 9-mer epitope fitted well into the peptide-binding groove of HLA-A*0201. In conclusion, the 19-mer epitope cluster was shown to have the potential for use as a vaccine candidate against dengue.

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Abstract-The purpose for wireless sensor networks is to deploy low cost sensors with sufficient computing and communication capabilities to support networked sensing applications. Even when the sensors are properly calibrated at the time of their deployment, they develop drift in their readings leading to biased sensor measurements. Noting that a physical phenomenon in a certain area follows some spatio-temporal correlation, we assume that the sensors readings in that area are correlated. We also assume that the instantiations of drifts are uncorrelated. Based on these assumptions, and inspired by the resemblance of registration problem in radar target tracking with the bias error problem in wireless sensor networks, we follow a Bayesian framework to solve the Drift/Bias problem in wireless sensor networks. We present two methods for solving the drift problem in a densely deployed sensor network, one for smooth drifts and the other for unsmooth drifts. We also show that both methods successfully detect and correct sensor errors and extend the effective life time of the sensor network.Index Terms-Wireless Sensor Networks, sensor calibration, drift and bias, error detection and correction.