No abstract

BACKGROUND: The burden of diabetes has an enormous impact on population health, healthcare system and the economy. Due to the high incidence of diabetes with obesity documented all over India and throughout the world a study was conducted on 40 NorthEastern individuals with diabetes to see for any correlation between insulin resistance and obesity with BMI and WHR as obesity indicators. AIM: Aim of the study is to examine the predictive ability of insulin resistance in obese diabetic patients using anthropometric indices in the NorthEastern region of India. MATERIALS AND METHODS: The present study was carried out among 40 obese patients with type 2 diabetes mellitus. SUMMARY: Obesity is one of the major risk factors for diabetes mellitus. The study evaluates the relation between obesity and insulin resistance in the study population. CONCLUSION: The study showed a positive relation between obese diabetic individuals and insulin resistance. WHR (Waist Hip Ratio) was found to have more predictive value than BMI (Body Mass Index) for the level of insulin resistance.

BACKGROUND: Due to the high incidence of thyroid disorders in the North-Eastern population of India a study was undertaken in Guwahati Medical College to see the age related changes in the morphology of the gland in the cadavers of this region. AIM: The study was done to compare the dimensions of the thyroid gland in this population with different studies around the world to see if it can throw any light why thyroid disorders are more common in this population and help clinicians to deal better. MATERIALS AND METHOD: The specimens were divided into three groups according to their ages. Twenty ( 21) specimens (both male and female) were taken from each age group. Statistical analysis was done by paired t-test and t was taken as significant if the value of t was greater than 2.18. SUMMARY: A study of all together of 63 specimen were taken up to see if any morphological differences in dimension exists in various age groups viz. pediatrics, adults and elderly and co relate with findings of previous workers and was statistically analyzed. CONCLUSION: The study showed that there was no morphological difference of this population with that of previous studies done in other parts of the world. Perhaps a histological study in molecular level will throw more light why this stratum of population is so vulnerable to thyroid disorders.

Background and Objectives: Diabetes mellitus is a common metabolic disease leading to various systemic complications in the affected individuals if not properly controlled with timely interventions. There are various studies showing the toxic effects of high blood glucose and its oxidant derivatives in the pathogenesis of various complications of the disease. Glucose-6-phosphate dehydrogenase (G6PD) is the key enzyme of hexose monophosphate shunt which produces NADPH that protects the body from oxidative damage and prevents from development of various complications. Uncontrolled blood glucose level for a longer duration time diminishes the G6PD activity and can lead the body into complications. This study was conducted in North-East India to evaluate the difference of G6PD activity among diabetics and non-diabetics and to study the impact of hyperglycemia on the G6PD activity. Methodology: Fifty diabetic and fifty non diabetic subjects are selected from participants of age 45 to 76 yrs. Demographic data including age, sex, height, weight, duration of diabetes mellitus, presenting symptoms, medical history was taken. Blood pressure and BMI were also measured. Blood samples from each patients were sent for estimation of FBS and PPBS, G6PD screening test and enzyme kinetic study, blood urea and serum creatinine estimation and serum triglycerides estimation. Results: G6PD activity was found to be diminished in diabetic patients, mild to moderately in comparison to the control group. It was also found that the deficient activity was dependent upon the duration of diabetes mellitus but not on the severity of the condition.

No abstract