The present work was carried out to assess a water quality index (WQI) of the Loktak Lake, an important wetland which has been under pressure due to the increasing anthropogenic activities. Physicochemical parameters like temperature (Tem), potential hydrogen (pH), electrical conductivity (EC), turbidity (T), dissolved oxygen (DO), total hardness (TH), calcium (Ca), chloride (Cl), fluoride (F), sulphate (SO 2À 4 ), magnesium (Mg), phosphate (PO 3À 4 ), sodium (Na), potassium (K), nitrite (NO 2 ), nitrate (NO 3 ), total dissolved solids (TDS), total carbon (TC), biochemical oxygen demand (BOD), and chemical oxygen demand (COD) were analyzed using standard procedures. The values obtained were compared with the guidelines for drinking purpose suggested by the World Health Organization and Bureau of Indian Standard. The result shows the higher concentration of nitrite in all the location which is beyond the permissible limit. Eleven parameters were selected to derive the WQI for the estimation of water potential for five sampling sites. A relative weight was assigned to each parameter range from 1.46 to 4.09 based on its importance. The WQI values range from 64 to 77 indicating that the Loktak Lake water is not fit for drinking, including both human and animals, even though the people living inside the Lake are using it for drinking purposes. The implementation of WQI is necessary for proper management of the Loktak Lake and it will be a very helpful tool for the public and decision makers to evaluate the water quality of the Loktak Lake for sustainable management.

The COVID-19 pandemic has affected 215 countries and territories around the world with 60,187,347 coronavirus cases and 17,125,719 currently infected patients confirmed as of the 25th of November 2020. Currently, many countries are working on developing new vaccines and therapeutic drugs for this novel virus strain, and a few of them are in different phases of clinical trials. The advancement in high-throughput sequence technologies, along with the application of bioinformatics, offers invaluable knowledge on genomic characterization and molecular pathogenesis of coronaviruses. Recent multi-disciplinary studies using bioinformatics methods like sequence-similarity, phylogenomic, and computational structural biology have provided an in-depth understanding of the molecular and biochemical basis of infection, atomic-level recognition of the viral-host receptor interaction, functional annotation of important viral proteins, and evolutionary divergence across different strains. Additionally, various modern immunoinformatic approaches are also being used to target the most promiscuous antigenic epitopes from the SARS-CoV-2 proteome for accelerating the vaccine development process. In this review, we summarize various important computational tools and databases available for systematic sequence-structural study on coronaviruses. The features of these public resources have been comprehensively discussed, which may help experimental biologists with predictive insights useful for ongoing research efforts to find therapeutics against the infectious COVID-19 disease.

A structured literature review using the search term 'ecosystem services' found few relevant studies relating to three contrasting wetlands in West Bengal: the unpopulated Sudhanyakhali Island in the Sundarbans National Park, the populated Gosaba Island separated from Sudhanyakhali Island by a narrow channel, and the East Kolkata Wetland (EKW). Subsequent structured review focused on the EKW using specific service-related terms located only 2 provisioning, 6 regulating, 1 cultural and 3 supporting services. Few services are currently recognized in the literature, with significant gaps in whole service categories. Significantly, there was no published evidence of a systemic overview of service production at these sites. Field observations and stakeholder dialogue informed assessment of ecosystem services using the Rapid Assessment of Wetland Ecosystem Services (RAWES) approach, adopted by the Ramsar Commission, on both islands and three discretely different areas of the EKW. The RAWES surveys found that 32 of 36 ecosystem services were produced from at least one assessed wetland site. Despite low sample size, statistically significant differences were observed in the range of services produced between the five wetland sites and the Electronic supplementary material The online version of this article (

Wetland contributes to human well-being and poverty alleviation. The increase in human population leads to more demand for water and degradation of the water bodies around the globe, resulting in scarcity of water. The aim of the present study was to assess the impact of anthropogenic activity on the water quality of the Loktak lake. Water samples were collected seasonally, namely, monsoon, post monsoon, winter and pre-monsoon, during 2013-2014 from 10 sites. For each water sample, 20 physicochemical parameters were analysed using the American Public Health Association method. Furthermore, 11 significant parameter values were used to develop the water quality index (WQI). The result shows high concentrations of nitrite (5.45-11.83 mg/l) and nitrate (93.67-177.75 mg/l) in rivers which is beyond the permissible limit and higher compared to the Loktak. Highest turbidity was observed at Langthabal with 21 NTU, which is above the permissible limit. The WQI of the Loktak ranged from 64 to 77, while for rivers they ranged from 53 to 95, which indicates that the water is in a very poor state. The WQI values of rivers are higher compared with those of the lake, and it was identified that water from the rivers is a major reason for increase in pollution in the lake water. The study suggests the need for long-term monitoring of the lake aquatic ecosystem and identification of pollution sites for proper management of the lake water. The WQI is an important tool to enable the public and decision makers to evaluate the water quality of the Loktak lake.