The abrasive characteristics of LM6 alloys are difficult to machine, so designing a technology that allows for effective machining is essential. This paper aims to evaluate the effect of process variables, namely feed rate, spindle speed and drill material, towards the responses like Thrust force, Surface roughness and burr height when drilling of LM6 alloy. LM6 aluminium alloy was fabricated by the stir casting process. Experiments were conducted using L9 orthogonal array in a Vertical Machining Centre coupled with a dynamometer for measuring thrust force. Surface roughness was found by Surface roughness tester and burr height was measured using Vision Measuring System. The findings show that the created model can accurately estimate the thrust force (TF), surface roughness (SR) and burr height (BH) in LM6 alloy drilling within the parameters examined.