Low back pain is very disabling and dispiriting because of the physical impediment it causes and its psychological effects. Innumerable factors have been implicated in its etiology. In spite of improvements in diagnostic modalities, a considerable number of such cases fall in the ambiguous zone of unknown etiology or 'idiopathic.'Early diagnosis of low back pain will allow effective prevention and treatment to be offered. This study was conducted to assess the contribution of vitamin D levels and other biochemical factors to chronic low back pain in such cases. All patients attending the orthopedics OPD for low back pain in whom a precise anatomical cause could not be localized, were prospectively enrolled in this study. We measured serum levels of glucose, calcium, phosphorus, uric acid, rheumatoid factor, C reactive protein, alkaline phosphatase, total protein, albumin and 25 (OH) D concentrations in 200 cases and 200 control samples. The patients showed significantly lower vitamin D levels compared to controls with p value \ 0.0001. The maximum number of low back pain patients were in the age group of 31-50 years (42 %).The average BMI was 23.27 ± 5.17 kg/sq m, 73 % of total patient population were females and 27 % were known case of type 2 diabetes mellitus. Calcium, alkaline phosphatase, was positively correlated with vitamin D and glucose showed a negative correlation with vitamin D in the patient population. The problem of low back pain provides a challenge to health care providers. The problem in developing countries is compounded by ignorance to report for early treatment and occupational compulsions in rural areas and sedentary lifestyle in urban youth. The authors strongly recommend early frequent screening for vitamin D along with glucose, protein, albumin, calcium, phosphorus, CRP as part of general health checkup for non-specific body pain, especially low back pain.

Exercise is known to induce weight loss which is more than expected due to energy expenditure during exercise. Till now the molecular mechanism of this disproportionate loss in weight was not known. A novel myokine, Irisin named after Greek goddess iris, discovered by Bruce M. Spiegelman et al. in 2012 [1] has been found to be the hormone responsible for exercise induced improvement in glucose homeostasis. It is a 112 AA polypeptide secreted from muscle into the bloodstream in response to exercise. There is 100 % homology in structure of Irisin between human and mice suggesting it to be a highly conserved hormone during evolution. It is found to be responsible for browning of subcutaneous adipose tissue and thus it is responsible for antiobesity and antidiabetic effect [1].Regarding the biochemical nature, Irisin is a cleaved and secreted fragment of FNDC5 (FRCP2 and PeP). FNDC5 is synthesised as a type I membrane protein which undergoes proteolytic cleavage and this results in release of N terminal part of protein into extracellular space. FNDC5 consists of three parts, a signal peptide, two fibronectin domains, hydrophobic domain and a C-terminal peptide. FNDC 5 is a glycoprotein. It is released from muscle in response to exercise [2, 3].As per the molecular mechanism, exercise is the stimulus for release of PGC1a (PPAR-co-activator-1a) which is

Objective: To estimate routine biochemical parameters Liver