Background: Some early staged NSCLC appears as non-subpleural peripheral pulmonary nodules. Thoracic surgeons usually adopt extended wedge resection or segmentectomy to remove these nodules. Video-assisted thoracoscopic surgery (VATS) has been carried out extensively worldwide in lung surgeries. The purpose of this study was to evaluate changes in postoperative pulmonary function changes after undergoing VATS wedge resection and VATS segmentectomy anatomical lung ‏resection. Methods: This retrospective study was carried out on 80 patients scheduled for UVATS sublobar resection lung surgery. Patients were divided equally into two groups according to the surgical procedures, VATS wedge resection group, and VATS segmentectomy group. All patients were subjected to full history taking length of stapler on CT scan, preoperative and postoperative pulmonary function tests include Forced vital capacity (FVC), Forced expiratory volume (FEV1), FEV1/FVC ratio, operation characteristics, postoperative recovery, treatment and hospitalization expenses. Results: FVC loss after segmentectomy was significantly greater than after wedge resection (17.1 ± 1.58%, vs. 7.9 ± 1.59% P < 0.001). Preoperative pulmonary function (FEV1 and FVC) was statistically different between the two groups of patients. Postoperative pulmonary function (FEV1, FVC and FEV1/-FVC) was statistically different between the two groups of patients.

Background: A major cause of cancer-related death is non-small-cell lung cancer (NSCLC). As only 20 % of NSCLC cases are typically discovered while the illness is potentially curable & resectable, resulting in poor 5-year survival rate. Objective: To compare between conventional versus VATS lobectomy in surgical treatment of NSCLC. Patients and Methods:This prospective randomized open label clinical trial involved 100 patients aged >18 years old sex diagnosed with NSCLS at Benha university. Randomly, cases were classified into 2 equal groups by computer generator into group A (n=50): underwent open thoracotomy, and group B (n=50): underwent VATS. All patients were subjected to full history taking, general examination such as vital signs and laboratory investigations were recorded. Results: Group A had significant increased duration of operation, prolonged air leak, & atelectasis than group B (P value <0.001, 027, 0.030 respectively). Pneumonia, hemothorax, AF, cerebrovascular accident and wound infection were insignificantly different between both groups. Group B had significant lower ICU stay & hospital stay than group A. Bleeding, readmission, recurrence, and mortality were insignificantly different between both groups. Group B had significant higher mean survival rate than group A. Conclusion: Open lobectomy was accompanied with a reduced survival rate and more comorbidities than VATS lobectomy. These findings imply showed that for treating NSCLC at an early stage, VATS is a safe & efficient method.