Background: Obstructive sleep apnea (OSA) is a prevalent sleep disorder known to be associated with cardiovascular risk factors and metabolic syndrome (MetS). The studies on OSA burden in MetS patients in India is scarce. Aim: To study prevalence of OSA in MetS and to study factors associated with OSA among MetS. Settings and design: Hospital based cross-sectional study was conducted for 2 years (year 2015-2016) at a Tertiary Care Teaching Hospital in Pune. Materials and Methods: MetS patients aged ≥18 years, of either sex were included in this study. Polysomnography was performed in all patients and grading of OSA severity was based on the apneahypopnea index (AHI). Statistical analysis: Data was analyzed in SPSS V:20. To find association of OSA with MetS and its components, statistical tests like chi-square, independent student t-test and One-way ANOVA test were applied. Results: Study prevalence of OSA among MetS patients was 73.3%. Relatively older age group (50.68±14.15years), male sex (81.0%), obesity (84.4%). Among OSA group, Mild OSA was present in 40.91%, moderate grade OSA in 31.8% and severe grade OSA in 27.27%. Severe grade OSA was significantly associated with older age (45.67 ± 14.3 years), obesity (35.75±8.3 Kg/m2), higher serum triglyceride and lower HDL-C levels, larger waist (110.75±11.9cm) and neck circumference (40.58±5.2cm). Conclusions: Central obesity, larger waist circumference, dyslipidemia were striking features of OSA patients that were significantly associated with severe grades of OSA. A trend of increased fasting blood sugar levels, systolic and diastolic blood pressure levels were noted in severe OSA groups. Thus, OSA is associated with higher levels of metabolic dysfunction.