The case of a 66-year-old patient is reported in view of the rarity of his condition: a case of subacute encephalopathy with seizures in alcoholics (SESA syndrome), described first in 1981 by Niedermeyer, et al. Wernicke-type aphasia, epileptic seizures (generalized tonic-clonic) and PLEDs EEG pattern dominated the neurological picture, in addition to hepatomegaly and rhabdomyolysis. This condition differs from all other known CNS complications in chronic alcoholism and is withdrawal-independent. It is prognostically favorable as far as the syndrome as such is concerned.

Following ten years of continuous olanzapine therapy a 51 years old man developed a Gilles de la Tourette syndrome which disappeared after changing to amisulprid. The Tourette-syndrome will be attributed to a tardive dyskinesia induced by olanzapine.

A case of a kleptomaniac with frontal lobe dysfunction is presented. Kleptomania is related to the obsessive-compulsive spectrum disorders and the affective spectrum disorders. In obsessive-compulsive spectrum disorders neuroimaging and neuropsychological tasks have revealed abnormal functioning in the frontal brain which also could be related to kleptomania. Consolidated findings from animal and human studies have implied central serotonergic transmission in the genesis of obsessive-compulsive spectrum disorders and affective spectrum disorders. Altogether, these results suggest that kleptomania, like other disorders of the above mentioned spectrums, could have an abnormality in serotonergic transmission in common.

Disturbances of thermoregulation are a well-known side effect of neuroleptic treatment, especially hyperthermia. Hypothermia can occur also during treatment with neuroleptics. Now hypothermia is more and more due to atypical neuroleptics in relation to 5-HT antagonism. We report the case of a patient (92 years) suffering from dementia with a hypothermia during treatment with aripiprazole.

ZusammenfassungDas Auftreten einer Hypersexualität bzw. einer sexuellen Enthemmung bei Anwendung von verschiedenen Neuroleptika stellt eine Rarität dar. Bei Anwendung von Aripiprazol häufen sich jedoch Mitteilungen, nach denen es zu einer sexuellen Enthemmung bzw. auch anderen Impulskontrollstörungen wie dem pathologischen Spielen kommt. Verantwortlich dafür ist möglicherweise der Partialagonismus am D2-Rezeptor oder auch die Stimulation am 5-HT1A-Rezeptor und der 5-HT2A-Rezeptoren-Antagonismus.