AIM:To evaluate the efficiency and safety of simultaneous, combined cryotherapy and alcohol injection in cases of secondary neovascular glaucoma with absolute vision loss and intolerable pain syndrome. Ocular pain due to glaucoma can be complex and difficult to treat. Therapy consists of topical and systemic pressure lowering agents, anti-inflammatory drugs, analgesics, surgical procedures -cyclocryotherapy, retrobulbar alcohol injection, enucleation or evisceration. MATERIALS AND METHODS:We present 35 patients diagnosed with absolute glaucoma and treated with a combined technique -cyclocryotherapy and retrobulbar alcochol 96% 1ml injection. Verbal Analog Score (VAS) was used to evaluate the pain. RESULTS:All of the patients (100%) were pain-free 12 months after the procedure. No significant longterm complications were observed. CONCLUSION:This case study highlights that cyclocryotherapy combined with retrobulbar alcohol can play a significant role in the management of pain in patients with absolute glaucoma.