Mortality in patients with severe trauma is mainly determined by the severity of HI, while TEI contribute consistently only from AIS grade 4 or higher.

Aim and Background: Scientific approach is the utilization of the new generative manufacturing process termed Selective Laser Melting (SLM) for the creation of biocompatible three-dimensional (3-D) bone substitutes made of the titanium alloy TiAl6V4. The SLM technique enables direct transfer of virtual 3-D structures into solid metal materials with full serial characteristics and typically great freedom of geometric design. Material and Methods: Individual 3-D CAD data which are derived from computed tomography models of anatomic structures are subdivided into layers of defined thickness. The actual part is generated by a repeating process of applying TiAl6V4 powder in layers of 0.003-0.1 mm on the process chamber platform transferring the area and contour information of each layer into the material using a laser beam. The physical process is a complete remelting of the powder with a metallurgical bonding between the layers yielding densities of approximately 100%. This operation is repeated step by step until the generation of the 3-D part is completed. We cultured human primary osteoblast-like cells on different surfaces of SLMmanufactured TiAl6V4 parts to prove osteoblast compatibility. Proliferation, vitality, and alkaline phosphatase (AP) activity of osteoblast cultures are presented. Results: It has become possible to produce complex 3-D geometries with different surface properties within few hours. Compatibility of the tested TiAl6V4 material with human osteoblasts is demonstrated. The cultured cells attach and proliferate on SLM substrates and show AP activity. Conclusions:The presented results demonstrate the potential offered by the SLM process. On the basis of scanned information, the generation of complex anatomic structures is realizable. The presented promising advantages make this procedure interesting for the production of individual implants or bone substitutes.