A palladium-catalyzed direct C-H functionalization of glycals with cycloalkenones is described and a series of C-2 functionalized glycols were synthesized efficiently with cyclic enones. The direct C-H functionalization of glycals...

A Lewis acid-mediated highly regio and stereoselective chiral azidation of C2-substituted glycals is reported. This strategy provides excellent, scalable, and mild reaction conditions for the stereoselective introduction of the azido...

Herein, we developed a site-selective Lewis acid-mediated transformation of pseudoglycals with various thiols for the synthesis of C-2 thioaryl glycosides. The substrate scope of the reaction was explored with various thiols having various functional groups on aromatic rings as well as with pseudoglycals obtained from different sugars. The compatibility and survival of various protecting groups on pseudoglycals and substituted thiols show tolerance under the reaction conditions. Finally, the potential synthetic utility of the synthesized compounds was demonstrated and also the late-stage modifications of various drugs and pharmaceuticals were also explored