Background: A fall is defined as an event in which a person inadvertently lands on the ground after falling from a higher place. It is the second most common cause of unintentional injury associated mortality after traffic accidents. Sometimes, when a body is brought for autopsy, it is unclear whether injuries are due to a fall from a height or due to blunt trauma from other causes. Objectives: This study aims to spotlight injuries in fatal falls from a height so that any pattern that might help discriminate between these injuries and injuries due to blunt trauma from other causes could be identified. Methods: This work included a retrospective study of fatal fall from height cases subjected to medico-legal autopsy in Tanta Department of Forensic Institute-Gharbia Governorate during the start of January 2012 at the end of October 2015. A cross-sectional study with autopsy was carried out on a fatal fall from height cases from the start of November 2015 to the end of October 2016. Results: The majority of cases (52.38%) were in the age group 20-40 years. Males registered 76.2% of cases. Urban areas recorded 64.3% of cases. The Head first impact was noticed in 66.7% of cases. Poly-trauma was the cause of death in 76.2% of cases. Nearly all cases showed diffuse head injuries involving bones, meninges, and brain and accompanying intracranial hemorrhage. The majority of cases registered negative drug screening. Conclusion: External injuries, including abrasions, contusions, and lacerations, were diffusely involving different body regions except for the neck. Skull fractures are distributed evenly amongst vault and base. Polytrauma is the most predominant cause of death. After the brain, thoracic cage and lung injuries were encountered in more than half of the cases. The liver is the most common abdomino-pelvic organ involved.