A mild and efficient chemoselective N-deacetylation using the Schwartz reagent at room temperature in rapid time is described. The mild and neutral conditions enable orthogonal N-deacetylation in the presence of some of the common protecting groups (viz. Boc, Fmoc, Cbz, Ts). The deprotection conditions did not induce any epimerization at the chiral amino centre.

A practical and efficient catalytic system comprising CuI and DMAP has been developed for the oxidative homo-and heterocoupling of terminal alkynes under aerobic conditions at room temperature. The catalytic utility of DMAP for efficient oxidative coupling of terminal alkynes has been explored. The CuI-DMAP catalytic system avoids the need for excess base and specialized ligands in oxidative coupling. Short reaction times make this approach economical and environmentally friendly.

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A silver(I)-catalyzed method to access spiro-pyrrolidinedioneoxiranes has been developed. Silver hexafluoroantimonate was found to be an efficient catalyst for the epoxidation of aldehydes using donor-/acceptor-substituted vinyl diazosuccinimides as carbenoid precursors. The protocol has been found to be highly regio-and chemoselective, and works well with aromatic aldehydes containing electronwithdrawing and -donating groups to afford spiro-pyrrolidinedioneoxiranes with a broad substrate scope. Dr. Homi