Abstract-Sakurai-Newton (SN) delay metric [1] is a widely used closed form delay metric for CMOS gates because of simplicity and reasonable accuracy. Nevertheless it can be shown that the SN metric fails to provide high accuracy and fidelity when CMOS gates operate at low supply voltages. Thus it may not be applicable in many low power applications with voltage scaling. In this paper, we propose a new closed form delay metric based on the centroid of power dissipation. This new metric is inspired by our key observation and theoretic proof that the SN delay is indeed Elmore delay, which can be viewed as the centroid of current. Our proposed metric has a very high correlation coefficient (≥ 0.98) when correlated with the actual delays got from the HSPICE simulations. Such high correlation is consistent across all major process technologies. In comparison, the SN metric has a correlation coefficient between (0.70, 0.90) depending upon the technology and the CMOS gate, and it is less accurate for lower supply voltages. Since our proposed metric has high fidelity across a wide range of supply voltages yet a simple closed form, it will be very useful to guide low voltage and low power designs.

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Background: Autoimmunity has increased significantly, alarmingly secondary to global contraception, abortion, fragmenting germ cells; herewith three types of life threatening manifestations, are analysed. Case-1: 28-year-old afebrile lady, vegetarian, presented to emergency with impaired responsiveness, deep jaundice, menorrhagia of one day duration and she had been taking native treatment with leaves for primary infertility for the past five years; she had a few ecchymotic patches, investigations showed severe anaemia, thrombocytopenia, haemolytic jaundice, peripheral smear confirmed thrombotic thrombocytopenic purpura; she developed profound hematuria; she received treatment with intravenous immunoglobulin, fresh frozen plasma, platelet transfusions, packed red blood cells transfusions, plasmapheresis was planned; she improved gradually. In her sincere effort to conceive a baby, for the past five years, due to cultural ignorance which teaches only three days abstinence,

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Androgen insensitivity syndrome (AIS), also known as testicular feminization, an X-linked recessive disorder comprises a wide range of phenotypes that are caused by various types of mutations in the androgen receptor gene. AIs can be classified as complete, partial, or mild based on the phenotypic presentation. The clinical findings include a female type of external genitalia, 46-XY karyotype, absence of Mullerian structures, presence of Wolffian structures to various degree, and normal to high testosterone and gonadotropin levels. We report this case as an interesting and rare syndrome. The patient is a 15-year-old phenotypic female who presented with primary amenorrhea and normal-appearing external genitalia. Orchidectomy was done after proper counselling and proper psychological support was given to her.