Background: India started Covid-19 vaccination from January 16, 2021 after the approval of two candidate vaccines namely Covishield TM and Covaxin TM .We report antibody responses among healthcare workers following two doses of CovishieldTM vaccination in a tertiary care setting. Methods: This prospective serosurveillance study was done among healthcare workers of JMMC&RI ,vaccinated during January to March 2021. Blood samples were drawn from 170 participants after their 1st dose and from 156 participants after their 2nd dose of COVID vaccine to measure the specific antibodies against the recombinant S1 subunit of the S protein of SARS CoV 2 Results: The median level of anti SARS CoV-2 Ig G antibody 28 days after the first dose vaccination is 3.64 S/C (IQR=5.91) and 11.6 S/C (IQR= 5.97) after 14 days of second dose vaccination. Protective levels of anti SARS CoV-2 Ig G antibodies is developed by 25 participants (14.7%) after 28 days of first dose of vaccination and by 109 participants (69.9%) after 14 days of second dose. 18-44 years age group (p=0.027) and absence of comorbidities (p=0.079) are associated with protective IgG levels. Conclusions: Rise in specific Ig G is observed after vaccination. Higher antibody response is observed with younger age group and absence of comorbidities, though statistically not significant. The influence of BMI is also not significant.
BACKGROUND Glycated haemoglobin (HbA1c) is used as a gold standard for monitoring glycaemic control of patients and is used as a predictor of diabetes-related complications. The HbA1c fraction is abnormally elevated in chronic hyperglycaemic states, like diabetes mellitus and it correlates positively with the glycaemic as well as metabolic control. Conditions that affect erythrocyte turnover affect HbA1c levels. The aim of this study was to determine the effect of microcytic anaemia on the HbA1c levels in non-diabetic patients, so as to analyse whether microcytic anaemia influences the HbA1c levels. MATERIALS AND METHODS A descriptive comparative study with a convenient sample size of 100 non-diabetic, anaemic patients and 100 age-matched nondiabetic non-anaemic controls were chosen. The patients who had glucose tolerance abnormalities (Impaired glucose tolerance or diabetes mellitus), blood loss, haemoglobinopathies, haemolytic anaemia, infestation, chronic alcohol ingestion and chronic liver or renal failure were excluded from the study. Relation of HbA1c with MCV was calculated using Chi square test. And also, HbA1c levels were compared between both the groups and analysed using independent t-test and its correlation with microcytic anaemia was calculated. RESULTS The mean HbA1c level of the non-diabetic patients with microcytic anaemia (6.89 ± 0.55 %) was higher than that in the nonanaemic controls (5.35 ± 0.28 %) (p< 0.001). CONCLUSION Microcytic anaemia definitely has an impact on the HbA1c levels. In patients with microcytic anaemia, as the MCV decreases, the values of HbA1c tends to rise spuriously, probably because, the glycation of the globin chain, in the relative absence of iron would occur more readily.
Background and Objectives: The ongoing COVID-19 pandemic is creating major disruptions globally at all levels of health care. The novel challenges affecting the efficiency of blood transfusion services range from uncertain patterns of demand for blood components to reductions in the numbers of donations and staffing because of lockdown and quarantine.1 The authors attempt to evaluate the impact of COVID-19 on blood transfusion services and the strategies used in the state of Kerala. Methods: A Google Form questionnaire was framed and was sent across all the blood centres in the state of Kerala through e-mail and other social media platforms; taking into account the various strategies taken to ensure a safe blood supply. Results: Only 28% rvesponded. 85% had reduction in blood. 99% had a specific COVID screening questionnaire. 80% had thermal screening and frequent cleaning. 35% used disposable bed sheets and implemented a token/prior appointment system. Only 10% conducted donation camps. 76% had shortage of staff due to lockdown. 90% had a shift system in the form of work arrangement. 35% were not provided PPE as they had shortage. 57% had a reduction in their salary. Only 7% blood centres faced shortage in consumables. 23% had an increased wastage in blood components and a few reagents. Only 7.5% of the centres were involved in CCP collection. 99% of the blood centres were willing to be part of CCP collection if the need arises. Conclusion: The BTS is responsible to provide an uninterrupted blood supply and it requires coordination at every level. Staff safety in the form of PPE and security in the form of salary should not be deprived of as health-care workers are the main pillars in the fight against COVID-19. The BTS in Kerala responded to the pandemic by strictly following the NBTC guidelines. When the need arises, the infrastructure at various blood centres has to be utilized so that the treatment outcomes of COVID-19 are also improved.
BACKGROUND Acute coronary syndrome is a set of signs and symptoms due to rupture of a plaque and is a consequence of platelet rich coronary thrombus formation. Platelet parameters, especially MPV could be an important and reliable marker in early detection of acute coronary syndrome when other markers are not available. Aim-To study the effect of platelet count and their indices, platelet volume and platelet distribution width and their prognostic significance in acute coronary syndrome. MATERIALS AND METHODS This was a case control study, and sample size was taken for convenience. Patients admitted to Rajiv Gandhi Government General Hospital, Madras Medical College, Chennai during the period extending from April 2016 to September 2016, were included in the study for convenience sake. A total of 100 patients were included in the study, in which 50 patients were cases admitted with chest pain and diagnosed as ACS. The control group considered of 50 age matched subjects who were admitted for chest pain evaluation and subsequently found to be non-cardiac chest pain after performing relevant investigations. Blood samples were taken at the time of admission for platelet parameters. RESULTS A total of 50 patients with acute myocardial infarction and 50 age matched controls were studied. The mean platelet count of the cases was 4.98±0.23 lakhs/mm³ and that of controls was 1.29±0.42 lakhs/mm³. Mean Platelet Volume (MPV) was significantly elevated in acute myocardial infarction (10.2±1.1 femtolitres) when compared with controls (8.29±0.9 femtolitres). CONCLUSION Platelet parameters mainly MPV and PDW are readily available and relatively simple and inexpensive laboratory tests, which were detected to be significantly raised in patients who have suffered an acute coronary syndrome.
Background: C-reactive protein (CRP) is well known as a marker of inflammation associated with cardiovascular diseases (CVD). Methods: The study group included was patients whose CRP level was above 7 mg/L diagnosed with acute myocardial infarction as case and normal healthy donors were taken as control. Results: In our study we have found that antioxidant such as glutathione (GSH) and Glutathione peroxidise (GPx) activity was decreased in blood of patients with acute Myocardial infarction (AMI) with elevated CRP compared to healthy control. We have also found that proxidant molecule such as malondialdehyde (MDA) was increased in AMI in comparison with control. Conclusion: The study concluded that in acute MI associated with inflammation there is imbalance in redox balance.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.