Summary: Polyetheretherketone (PEEK) implants are being increasingly used to reconstruct defects in the oral and maxillofacial region. This article reports a special case of a patient with major destruction in his maxilla due to a war injury. The resultant defect was reconstructed with a 3D-printed, patient-specific, PEEK implant, restoring acceptable function and aesthetics. The patient followed up for 13 months and showed no technical or biological complications, proving the reliability of this treatment option for recreating severe maxillofacial deformities, and benefiting from the advantage they offer, which is eliminating the need for additional surgery to harvest autogenous bone grafts. Thus, when applicable, the use of PEEK implants could be a possible alternative to other treatment modalities.