Colorectal cancer is the third most common cancer diagnosed in the United States. Majority of patients have localized disease that is amenable to curative resection. Disease recurrence remains a major concern after resection. In addition, patients are at an increased risk for developing a second or metachronous colon cancer. The principal goal of surveillance following treatment of colon cancer is to improve disease-free and overall survival. Survivorship is a distinct phase following surveillance to help improve quality of life and promote longevity.
We read with great interest the article entitled, "Paranuclear dot-like immunostaining for CD99: A unique staining pattern for diagnosing solid-pseudopapillary neoplasm of the pancreas" authored by Dr. Xiao and colleagues. The authors describe a unique paranuclear dot-like immunoreactivity for CD99 in neoplastic epithelial cells of solid-pseudopapillary neoplasms of the pancreas, different from the expected cellular immuno-localization along the cell membrane, indicative of intercellular cohesive signaling. The authors utilize this unique immunostaining pattern to distinguish solid-pseudopapillary neoplasms from other pancreatic solid tumors.
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