BACKGROUNDPost-transplant lymphoproliferative disorder (PTLD) is a fatal complication of solid organ transplantation or allogenic hematopoietic stem cell transplantation that is associated with immunosuppressive therapy. Potential manifestations are diverse, ranging from reactive lymphoid hyperplasia to high-grade lymphoma. PTLD is usually of B-cell origin and associated with Epstein-Barr virus (EBV) infection. Herein, we describe a case of PTLD involving the peritoneal omentum. There has been only case of PTLD as a diffuse large B-cell lymphoma (DLBCL) in the peritoneum.CASE SUMMARYThe patient was a 62-year-old man who had been receiving immunosuppressive therapy with tacrolimus since undergoing a liver transplant 15 years prior. He reported that he had experienced abdominal discomfort and anorexia 1 month prior to the current admission. Abdominal pelvic computed tomography (CT) revealed peritoneal and omental mass-like lesions without bowel obstruction. Ultrasonography-guided biopsy was performed, and he was histologically diagnosed with EBV-negative DLBCL. Positron emission tomography (PET)-CT depicted peritoneum and omentum involvement only, without any lymphadenopathy or organ masses, including in the gastrointestinal tract. Six cycles of chemotherapy with a “R-CHOP“ regimen (rituximab-cyclophosphamide, doxorubicin, vincristine, prednisolone) were administered, and PET-CT performed thereafter indicated complete remission.CONCLUSIONThis is the first report of isolated peritoneal lymphomatosis defined as PTLD in a liver transplant recipient.
Malignant lymphoma of the uterine cervix is rare with non-specific clinical presentation and is di ficult to diagnose via cervical cytology. The current study presents a case of primary malignant lymphoma of the uterine cervix diagnosed via initial conventional smear cytology and subsequent cervical biopsy. We present a case of an 81-yearold woman with vaginal bleeding post-urination. The conventional smear cytology showed scattered large atypical lymphoid cells with necrotic debris. The concurrently biopsied specimen revealed large monotonous atypical lymphoid cells, which were immunoreactive for CD20 with high Ki-67 proliferative index, consistent with di fuse large B-cell lymphoma (DLBCL). Due to the transfer of the patient to another hospital, any other examinations associated with staging were not performed. Although rare, the likelihood of malignant lymphoma should be considered while screening for cervical cancer through cytology using Pap smear or conventional smear. Cytological screening may be useful for the early diagnosis of malignant lymphoma of the uterine cervix. Immediate and appropriate treatment can be initiated with a quick and accurate diagnosis. Herein, we report a case of primary uterine cervical DLBCL and review the literatures comprising 106 cases studies with 255 cases of primary cervical lymphoma reported since 1980 including clinical and histological characteristics through MEDLINE database.
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