Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer’s disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD. We developed a model that predicts brain age from resting state (rs)-fMRI data, and assessed whether genetic determinants of AD, as well as beta-amyloid (Aβ) pathology, can accelerate brain aging. Using data from 1340 cognitively unimpaired participants between 18–94 years of age from multiple sites, we showed that topological properties of graphs constructed from rs-fMRI can predict chronological age across the lifespan. Application of our predictive model to the context of pre-clinical AD revealed that the pre-symptomatic phase of autosomal dominant AD includes acceleration of functional brain aging. This association was stronger in individuals having significant Aβ pathology.

This chapter presents various application methods, formulations and biological considerations on the modes of action of mycopesticides used to control insects, weeds, nematodes, and fungal pathogens. It also includes some important concepts in spray application and case studies on mycopesticide application.

ment many months; indeed, all the sores are not yet healed. For this case I get nothing more than the 304th part of £ l7 10s., or Is. 1½d. Compare this with the payments made to my colleagues, who have not performed any operations of importance during the last two years and a half, (excepting in one instance-tapping a woman;) whilst I have had to amputate a limb above the knee, remove part of a hand, a tumour of importance from a child's side, resect an elbow-joint, and operate for strangulated hernia. One gentleman has a salary that gives him 2s. 2¼d. per order; a second, 4s. 11½d.; and a third, 16s. 3¼d.; and I have but 18. 3 3/4d.

SL309, a 6-page illustrated report by Maria L. Silveira, Randy Bateman, Joseph Walter, Jerry Sartain, Christa L. Kirby, and Pete Deal, presents the results of a study to evaluate P removal rates in different sod production systems in central and south Florida. Includes references. Published by the UF Department of Soil and Water Sciences, November 2009. SL 309/SS521: Phosphorus Removal Rates from Sod Production Systems (ufl.edu)

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