Type 16 and Type 18 Human Papilloma Virus are highly associated with cervical cancer. Vaccination against these two types has been proved to be the most successful method to control this sexually transmitted disease. The vaccines have also been proved to be safe, but unfortunately, the incidence is still rising. In this review, we consider the accumulated evidence that HPV vaccines are already reducing burned in cervical cancer and preventing HPV infection, summarize the efficacy from different angles from scientific, social and economy while discussing the new generation nine-valent HPV vaccines.