The glandular odontogenic cyst (GOC) is a rare jaw development cyst that exhibits aggressive biological behavior and is prone to recurrence. The present study aims to report a case of GOC with an emphasis on its clinical, diagnostic, and therapeutic aspects. A 40-year-old female patient presented to the Buccomaxillofacial Surgery service with a swelling in the anterior mandible. Histopathological analysis revealed a cystic cavity lined by a non-keratinized epithelium of varying thickness, exhibiting many features consistent with GOC, such as mucous cells and duct-like microcystic spaces. Lesion resection was performed, followed by immediate reconstruction. After one year of follow-up, the patient is free of recurrence. Therefore, this case highlights the importance of an effective diagnosis of GOC, through a clear definition of histopathological criteria, to provide the most appropriate treatment and absence of relapses.
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