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Epilepsy is a disorder that is best viewed as symptoms of disturbed electrical activity in the brain, which may be caused by a wide variety of etiologies. It is a collection of many different types of seizures that vary widely in severity appearance, cause, consequence an management. The present study was done to evaluate, which drug is more effective than the other AED, used in tertiary care hospital. We studied and analyzed the pattern usage of AED in tertiary care hospital. And evaluated the incidence of side effects of these drugs on the subjects in the study, studied the compliance to various recommendations/protocols for usage of AED in neurology intensive care unit, and also compared the commonest and least common anti epilepsy drugs in neurology care unit. Commonest drugs use in TBI, CVA, SAH, average age of patients having seizures. The required information was collected from the case sheets of individual patients in the designed data collection form. Patient details were collected through self designed, by patient interview, by prescriptions or by medication charts. The efficacy study conducted and was evaluated according to the declaration of ‖HELNSIKI‖ (as embedded 1996) an by the incidence of adverse event reported by the patients.

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