In addition to electrocardiogram (ECG), analysis of creatinine phosphokinase (CPK), lactate dehydrogenase (LDH) and their isoenzymes is commonlyemployed to diagnose acute myocardial infarction (AMI). The aim of this study was to observe the efficiency of isomers of CPKfor early diagnosis of AMI. ECG, though useful in many ways, is not 100% sensitive. The drawback involved with CPK and LDH isoenzymes is the time lag factor in diagnosing AMI early enough for interventional therapy. Recently the subunits of these isoenzymes, namely MMand now the MB isomers are being tested for their effectiveness in the early diagnosis ofAMI. In our experience MB isomers were found to be accurate markers in the early diagnosis of AMI. They were especially valuable in diagnosing myocardial infarction not detectable by ECGin cases such as non-Q AMI, cardiomyopathy, and bundle branch block among other such cases. (Internal Medicine 33: 210-215, 1994)

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