Purpose: To determine the potential role of several biochemical and clinical markers in predicting adverse pathology (AP) and ISUP GG upgrading at radical prostatectomy (RP) with low-grade (ISUP Gleason Group (ISUP GG) 1 and 2) prostate cancer (PCa). Methods: We retrospectively reviewed the patients who underwent radical prostatectomy following criteria: clinical stage T2a or less,and were identified low-grade PCa (ISUP GG 1−2, prostate-specifific antigen (PSA) <20 ng/ml) through prostate biopsy, univariate and multivariate analyses were performed to evaluate the association of patient and tumor characteristics with reclassification, AP was defined as stage ≥T3 and/or ISUP GG ≥3.Results: A total of 155 patients were eligible for this study. AP at RP occurred in 20 of 97 (20.62%) patients with ISUP GG 1, and 28 of 58 (48.28%) with ISUP GG 2. At univariate analysis, bioptic ISUP GG emerged as significant factors of AP(p＜0.001). Platelets to lymphocyte ratio(PLR) might be the risk factor of the incidence of AP(p=0.059). At multivariate analysis, we found PLR and bioptic ISUP were independent significantly factors in predicting AP. The area under the curve for PLR was 0.592. And also, we showed that systemic immune inflammation index(SII) and bioptic ISUP GG were significantly associated with ISUP GG upgrading after RP in multivariate analysis. Conclusions: We found that SII could not be a significant risk factor of AP at low-grade prostate cancer (PCa) after RP.While SII might be a predict factor for ISUP GG upgrading. PLR might be used as an independent predictor which was inversely correlated with presence of AP in low-grade PCa after RP.

OBJECTIVES: The purpose of this study was to explore the predictive value of preoperative prognostic nutritional index(PNI) and systemic immune‐inflammation index(SII) for local tumor stage in bladder cancer(BC) after radical cystectomy(RC).METHODS: We researched our database between April 2011 and October 2019. There were 195 BC patients who underwent RC. The PNI and SII were calculated using preoperative blood sample results. The predictive value of SII and PNI was analysed with univariate and multivariate Cox regression models. Significant P was P<0.05.RESULTS: Of patients, all patients were males with a mean age of 67.94±8.97years. Mean serum albumin was 42.13±4.28(g/L), mean PNI score was 51.29±6.09 and mean SII was 661.67±506.22. Multivariable Cox regression analysis demonstrated that PNI scores and SII could not play a significantly predictive factor between muscle invasive bladder cancer(MIBC) and non-muscle-invasive bladder cancer(NMIBC). While we also found PNI was an independent risk factors for predicting tumor stagep(pT＜3a and pT≥3a).CONCLUSIONS: Our research revealed that preoperative low PNI but not SII could be used as an independent factor to predict worse pathologically stage(pT≥3a). We still need future studies with large cohorts to identify our results.

Background: Anogenital distance（AGD） can be used as a biomarker to indirectly indicate androgen levels during the sexual maturation of mammals. In order to gain a deeper understanding of the association between the AGD and the risk of prostate cancer(PCa), we performed this studyMaterials: A total of 107 patients undergoing perineal prostate biopsy from November 2019 to August 2020 were enrolled. All patients diagnosed 57 PCa patients and 50 benign prostatic hyperplasia(BPH) patients through perineal prostate biopsy in our hospital . The anus to the posterior base of the scrotum (AGDAS) and the cephalad insertion of the penis (AGDAP) of all patients were measured before prostate biopsy.Result: The mean age of patients with PCa was 69.46 ± 7.52 and the mean age of patients with BPH was 67.38± 8.26. We did not find a significant association between age and BMI in the risk of PCa(all p＞0.05). Besides, there was no significant association between AGD and the risk of PCa(p＞0.05). we only discovered that PSA could play an important role in the development of PCa.Conclusion: AGD may not play an important role in predicting the incidence risk of PCa. we still need a large-scale prospective study to explore the ture association between AGD and the incidence of PCa.

Purpose: At present, there is no clear relationship between prostatitis and prostate cancer(PCa). Therefore, in order to further understand the inflammation of prostate tissue and the occurrence of PCa, we conducted this study.Method: A total of 686 patients were enrolled in the study. All patients underwent prostate biopsy in our hospital. A retrospective analysis of the biopsy results was performed to assess the assocition between chronic inflammation and the risk of PCa.Result: Of the 686 patients, 354 were diagnosed with PCa, and 332 were benign. A total of 403 patients had prostate inflammation. PCa patients had lower prostate volume and transition zone volume than benign group(p＜0.001). Compared with benign group, PCa patients had lower PSA and PSA density (PSAD)(p＜0.001). We also found that the probability of inflammation in PCa patients is lower than that in the benign group (p＜0.001). In multivariate analyses, chronic inflammation was negatively correlated with the incidence of PCa（OR=0.80; p=0.015). Conclusion: Chronic inflammation in biopsy tissue might serve as a predicted factor for low incidence risk of PCa.