The aim of study is to reduce hepatic damage from paracetamol will be funded using alcohol extract for ginger and vitamin E as antioxidants in male New Zealand rabbits. Paracetamol (acetaminophen) is a widely used over-the-counter analgesic and antipyretic drug which is known to cause liver injuries in both humans and experimental animals when administered in overdose. The current study was conducted at the animal house of the College of Veterinary Medicine, Tikrit University to detect certain side effects developed with the use of the drug paracetamol, some physiological values resulting from liver damage through the use of 40 male New Zealand rabbits aged 5-7 months, randomly divided into four equal groups, including: The control group were given the normal physiological solution and the second group were given the paracetamol drug was given orally 400 mg/kg per rabbit while the third group was given vitamin e 50 mg/kg body weight as well as 400 mg/kg of the paracetamol drug was given orally. The fourth group was dosed with ginger alcoholic extract of 150 mg/kg body weight, which was given 400 mg/kg of the paracetamol drug was given orally. The study's findings demonstrated a significant decrease in the levels of catalase (CAT), super oxidase dismutase (SOD) and glutathione (GSH) in the treatment with a paracetamol drug compared to the control group, as well as a significant increase in the levels of liver enzymes and malondialdehyde. The study's results also found a significant decline in the levels of liver enzymes and malondialdehyde while revealing a significant increase in the levels of CAT, SOD and GSH in 3 rd and 4 th group compared to 2 nd group. From the aforementioned findings, it can be concluded that vitamin e and ginger alcohol extract both reduce the unfavorable and harmful effects in some physiological parameters coming from liver damage caused by Paracetamol drug usage.
The study included 70 local buffalo animals (between six months and two years), 50 buffalo were confirmed to be infected with gastrointestinal worms and 20 were considering as a control group. The results of the feces tests showed that local buffalo was infected with different types of worms. It was observed that worm incidence was as follows: 85% Nematodes, 10% Cestode and 5% Trematode. The results of the study showed a significant decrease in the total number of red blood cells, hemoglobin concentration, packed cell volume, total number of platelets, and significant increase was observed in the total number of white blood cells and was most likely caused by a significant increase in the rates of eosinophil's. Also the results showed that the effect of worms on some biochemical parameters was significant decrease in total protein concentration, albumin, and globulin. So, it could be concluding that buffalo spread in the city of Samarra suffers from parasitic diseases that affect the health of animals, through change the study criteria, so a therapeutic program must be adopted by cattle breeders to control parasitic diseases and thus improve the health and production of animals.
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