Closed-loop auditory stimulation (CLAS) is a brain modulation technique in which sounds are timed to enhance or disrupt endogenous neurophysiological events. CLAS of slow oscillation up-states in sleep is becoming a popular tool to study and potentially enhance sleep's functions, as it can increase slow oscillations, evoke sleep spindles, and enhance memory consolidation of certain tasks. However, few studies have examined the specific neurophysiological mechanisms involved in CLAS, in part because of practical limitations to commonly-used tools. To evaluate evidence for possible models of how sound stimulation during brain up-states might generate slow oscillations, we simultaneously recorded electro- and magnetoencephalography in human participants who received auditory stimulation across sleep stages and neural oscillation phases. The results suggest that auditory information reaches ventral frontal lobe areas via non-lemniscal pathways. From there, a slow oscillation is created and propagated. We demonstrate that while the state of excitability of tissue in auditory cortex and frontal ventral regions shows some synchrony with the EEG-recorded up-states that are commonly used for CLAS, it is the state of ventral frontal regions that is most critical for slow oscillation generation. Our findings advance models of how CLAS leads to enhancement of slow oscillations, sleep spindles, and associated cognitive benefits, and offer insight into how the effectiveness of brain stimulation techniques can be improved.

People with psychotic disorders are at higher risk of not completing an educational degree and tend to get low-wage jobs. We offered computer coding classes to 14 participants. The training was deemed feasible, acceptable, and appeared to increase their motivation for school or work, not only in computer-related domains.