Understanding how the physical properties of Nano-silica material affect the ultimate implementation of the asphalt binder is an essential study area that has been disregarded previously. The current investigation aims to determine whether or not it was possible to change the asphalt binder with Nano-silica (NS) depending on the qualities of the asphalt binder under consideration. Using nano-silica (2, 4, and 6 percentage by weight of asphalt), a penetration grade asphalt cement with 60/70 was developed. Nano silica and asphalt cement were first tested for their qualities. The NS modified asphalt binder was ready for use in the experiment after being heated to 160°C and mixed with a shear mixer at 2000 rpm for 60 minutes. The softening point temperature and penetration index of the NS modified asphalt binder, as well as the Brookfield rotational viscosity and ductility data, were also evaluated. Based on the rheological performance of the NS modified asphalt binder, increasing Nano silica content increases stiffness while decreasing temperature sensitivity. The addition of 4% Nano silica (NS) asphalt binder improved its basic properties and allowed it to be used in hot weather. By adding 4% NS to the hot recycle asphalt mixture, the Marshall stability is increased by 32.5%, the flow is reduced by 21.4%, the unit weight is maintained, and the amount of air voids in the mix, as well as other mix qualities, are kept at acceptable ranges. It'll also boost the ITS by 37.8%. In general, adding NS to asphalt mixtures improves their qualities.

Background: Coriander (Coriandrum sativum L.) is grown as a spice crop all over the world. A few articles have linked the consumption of coriander to certain liver diseases but several articles have disputed these assertions and the consumption of coriander has been on the increase. Objective: This study aimed to determine the effects of oral administration of coriander on hepatocellular carcinoma in rats in order to compare biochemical findings with histological findings. Materials and Methods: Forty male and female albino rats were grouped into 5, consisting of 8 rats in each group. Group (1) was fed on the basal diet and tab water as a negative control group, while the other groups were fed on basal diet and injected with C. Diethyl Nitrosamine (DEN) to induce hepatocellular carcinoma in rats. Group (2) was left as a positive control, while groups (3), (4), and (5) were fed on experimental diets and oral administration of 1 g, 3 g, and 6 g of the Coriander, respectively, for 6 weeks.Their blood samples were analyzed for total and conjugated bilirubin, total protein, albumin, globulin, alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. The liver tissues were also processed for histological examination. Results: Examination of livers obtained from hepatocarcinogenesis rats in high concentration extract of coriander (6g) group revealed the best results compared with the other treatment groups in hepatic lobules. Conclusion:This study suggests that oral administration of coriander seed in high levels concentration extract for 6 weeks may be beneficial for patients suffering from hepatocarcinogenesis and liver disease as it improves liver function.